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Journal Article

An ancient evolutionary origin of genes associated with human genetic diseases

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons56653

Domazet-Lošo,  Tomislav
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons56962

Tautz,  Diethard
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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domazet-loso_2008.pdf
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Citation

Domazet-Lošo, T., & Tautz, D. (2008). An ancient evolutionary origin of genes associated with human genetic diseases. Molecular Biology and Evolution, 25(12), 2699-2707. doi:10.1093/molbev/msn214.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-D63D-8
Abstract
Several thousand genes in the human genome have been linked to a heritable genetic disease. The majority of these appear to be nonessential genes (i.e., are not embryonically lethal when inactivated), and one could therefore speculate that they are late additions in the evolutionary lineage toward humans. Contrary to this expectation, we find that they are in fact significantly overrepresented among the genes that have emerged during the early evolution of the metazoa. Using a phylostratigraphic approach, we have studied the evolutionary emergence of such genes at 19 phylogenetic levels. The majority of disease genes was already present in the eukaryotic ancestor, and the second largest number has arisen around the time of evolution of multicellularity. Conversely, genes specific to the mammalian lineage are highly underrepresented. Hence, genes involved in genetic diseases are not simply a random subset of all genes in the genome but are biased toward ancient genes.