Reproductive fitness advantage of BCR-ABL expressing leukemia cells.

Traulsen, Arne; Pacheco, Jorge M.; Dingli, David

doi:10.1016/j.canlet.2010.01.020

Item

ITEM ACTIONSEXPORT

Add to Basket

Release HistoryDetailsSummary

Released

Journal Article

Reproductive fitness advantage of BCR-ABL expressing leukemia cells.

MPS-Authors

/persons/resource/persons56973

Traulsen, Arne
Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Traulsen, A., Pacheco, J. M., & Dingli, D. (2010). Reproductive fitness advantage of BCR-ABL expressing leukemia cells. Cancer Letters, 294(1), 43-48. doi:10.1016/j.canlet.2010.01.020.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-D464-D

Abstract

Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. We utilize a model of chronic myeloid leukemia (CML), to quantitate the fitness advantage conferred by expression of BCR-ABL in hematopoietic cells from in vivo patient data. We show that BCR-ABL expression provides a high fitness advantage, which explains why this single mutation drives the chronic phase of CML.