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The evolutionary origin of orphan genes

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons56962

Tautz,  Diethard
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons56653

Domazet-Lošo,  Tomislav
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Zitation

Tautz, D., & Domazet-Lošo, T. (2011). The evolutionary origin of orphan genes. Nature Reviews Genetics, 12(10), 692-702. doi:10.1038/nrg3053.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000F-D397-1
Zusammenfassung
Gene evolution has long been thought to be primarily driven by duplication and rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes that lack homologues in other lineages and whose evolutionary origin is only poorly understood. Orphan genes might arise from duplication and rearrangement processes followed by fast divergence; however, de novo evolution out of non-coding genomic regions is emerging as an important additional mechanism. This process appears to provide raw material continuously for the evolution of new gene functions, which can become relevant for lineage-specific adaptations.