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Mate choice among yeast gametes can purge deleterious mutations

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Greig,  D.
Max-Planck Research Group Experimental Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Tazzyman, S. J., Seymour, R. M., Ponmiankowski, A., & Greig, D. (2012). Mate choice among yeast gametes can purge deleterious mutations. Journal of Evolutionary Biology, 25(8), 1463-1471. doi:10.1111/j.1420-9101.2012.02539.x.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-D35A-9
Abstract
Meiosis in Saccharomyces yeast produces four haploid gametes that usually fuse
with each other, an extreme form of self-fertilization among the products of a
single meiosis known as automixis. The gametes signal to each other with sex
pheromone. Better-quality gametes produce stronger signals and are preferred
as mates. We suggest that the function of this signalling system is to enable
mate choice among the four gametes from a single meiosis and so to promote
the clearance of deleterious mutations. To support this claim, we construct a
mathematical model that shows that signalling during automixis (i) improves
the long-term fitness of a yeast colony and (ii) lowers its mutational load. We
also show that the benefit to signalling is greater with larger numbers of
segregating mutations