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Journal Article

Columnar cells necessary for motion responses of wide-field visual interneurons in Drosophila

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons39057

Schnell,  Bettina
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons39033

Raghu,  Shamprasad Varija
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38770

Borst,  Alexander
Department: Systems and Computational Neurobiology / Borst, MPI of Neurobiology, Max Planck Society;

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Schnell, B. et al..pdf
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Citation

Schnell, B., Raghu, S. V., Nern, A., & Borst, A. (2012). Columnar cells necessary for motion responses of wide-field visual interneurons in Drosophila. JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 198(5), 389-395. doi:10.1007/s00359-012-0716-3.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-A4D9-B
Abstract
Wide-field motion-sensitive neurons in the lobula plate (lobula plate tangential cells, LPTCs) of the fly have been studied for decades. However, it has never been conclusively shown which cells constitute their major presynaptic elements. LPTCs are supposed to be rendered directionally selective by integrating excitatory as well as inhibitory input from many local motion detectors. Based on their stratification in the different layers of the lobula plate, the columnar cells T4 and T5 are likely candidates to provide some of this input. To study their role in motion detection, we performed whole-cell recordings from LPTCs in Drosophila with T4 and T5 cells blocked using two different genetically encoded tools. In these flies, motion responses were abolished, while flicker responses largely remained. We thus demonstrate that T4 and T5 cells indeed represent those columnar cells that provide directionally selective motion information to LPTCs. Contrary to previous assumptions, flicker responses seem to be largely mediated by a third, independent pathway. This work thus represents a further step towards elucidating the complete motion detection circuitry of the fly.