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Journal Article

Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction.

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons59192

Joseph,  A. A.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15516

Merboldt,  K. D.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15968

Voit,  D.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons16078

Zhang,  S.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15943

Uecker,  M.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15082

Frahm,  J.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

Fulltext (public)

1479547.pdf
(Publisher version), 441KB

Supplementary Material (public)

1479547_suppl_movie1.avi
(Supplementary material), 13MB

1479547_suppl_movie2.mpg
(Supplementary material), 15MB

Citation

Joseph, A. A., Merboldt, K. D., Voit, D., Zhang, S., Uecker, M., Lotz, J., et al. (2012). Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction. NMR in Biomedicine, 25(7), 917-924. doi:10.1002/nbm.1812.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-A256-3
Abstract
Velocity-encoded phase-contrast MRI of cardiovascular blood flow commonly relies on electrocardiogram-synchronized cine acquisitions of multiple heartbeats to quantitatively determine the flow of an averaged cardiac cycle. Here, we present a new method for real-time phase-contrast MRI that combines flow-encoding gradients with highly undersampled radial fast low-angle shot acquisitions and phase-sensitive image reconstructions by regularized nonlinear inversion. Apart from calibration studies using steady and pulsatile flow, preliminary in vivo applications focused on through-plane flow in the ascending aorta of healthy subjects. With bipolar velocity-encoding gradients of alternating polarity that overlap the slice-refocusing gradient, the method yields flow-encoded images with an in-plane resolution of 1.8 mm, section thickness of 6 mm and measuring time at 3 T of 24 ms (TR/TE = 3.44/2.76 ms; flip angle, 10º; seven radial spokes per image). Accordingly, phase-contrast maps and corresponding velocity profiles achieve a temporal resolution of 48 ms. The evaluated peak velocities, stroke volumes, flow rates and respective variances over at least 20 consecutive heartbeats are in general agreement with literature data.