de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons38894

Hofer,  Sonja
Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

van Versendaal, D., Rajendran, R., Saiepour, M. H., Klooster, J., Smit-Rigter, L., Sommeijer, J.-P., et al. (2012). Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity. NEURON, 74(2), 374-383. doi:10.1016/j.neuron.2012.03.015.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-9CEE-2
Abstract
During development, cortical plasticity is associated with the rearrangement of excitatory connections. While these connections become more stable with age, plasticity can still be induced in the adult cortex. Here we provide evidence that structural plasticity of inhibitory synapses onto pyramidal neurons is a major component of plasticity in the adult neocortex. In vivo two-photon imaging was used to monitor the formation and elimination of fluorescently labeled inhibitory structures on pyramidal neurons. We find that ocular dominance plasticity in the adult visual cortex is associated with rapid inhibitory synapse loss, especially of those present on dendritic spines. This occurs not only with monocular deprivation but also with subsequent restoration of binocular vision. We propose that in the adult visual cortex the experience-induced loss of inhibition may effectively strengthen specific visual inputs with limited need for rearranging the excitatory circuitry.