Liquid chromatography/Fourier transform ion cyclotron resonance mass 
spectrometry (LC-FTICR MS): an early overview

Schrader, Wolfgang; Klein, Heinz-Werner

doi:10.1007/s00216-004-2675-1

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Liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS): an early overview

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Schrader, Wolfgang
Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Klein, Heinz-Werner
Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Schrader, W., & Klein, H.-W. (2004). Liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS): an early overview. Analytical and Bioanalytical Chemistry, 379(7-8), 1013-1024. doi:10.1007/s00216-004-2675-1.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-9789-8

Abstract

Fourier-transform ion cyclotron resonance mass spectrometry has developed into one of the most powerful analytical techniques. This unique technique enables acquisition of high-resolution mass spectra with high accuracy, which in turn enables determination of the elemental composition of the analyzed compounds. Coupling with liquid chromatography affords a separation technique with a high-resolution “detector” which can be used to investigate very complex matrices. In this review some important instrumental developments are described and applications are presented; these show the advantages and disadvantages of this combination.