Metal‐Free, Organocatalytic Asymmetric Transfer Hydrogenation of 
α,β‐Unsaturated Aldehydes

Yang, Jung Woon; Hechavarria Fonseca, Maria T.; Vignola, Nicola; List, Benjamin

doi:10.1002/anie.200462432

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Metal‐Free, Organocatalytic Asymmetric Transfer Hydrogenation of α,β‐Unsaturated Aldehydes

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Yang, Jung Woon
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Hechavarria Fonseca, Maria T.
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Vignola, Nicola
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Yang, J. W., Hechavarria Fonseca, M. T., Vignola, N., & List, B. (2005). Metal‐Free, Organocatalytic Asymmetric Transfer Hydrogenation of α,β‐Unsaturated Aldehydes. Angewandte Chemie International Edition, 44(1), 108-110. doi:10.1002/anie.200462432.

Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-9667-D

Abstract

Selective reduction without metals: An imidazolidinone salt effectively catalyzes the highly enantioselective biomimetic transfer hydrogenation of α,β‐unsaturated aldehydes to give the saturated analogues using a synthetic dihydropyridine cofactor (see scheme). Remarkably only one enantiomer forms regardless of the configuration of the enal starting material.