English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis

MPS-Authors
/persons/resource/persons58380

Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons59058

Turet,  Laurent
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Fürstner, A., & Turet, L. (2005). Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis. Angewandte Chemie International Edition, 44(22), 3462-3466. doi:10.1002/anie.200500390.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000F-94E3-3
Abstract
Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne–yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology.