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Nucleosome repositioning via loop formation

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons48239

Kulic,  I. M.
MPI for Polymer Research, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons48698

Schiessel,  Helmut
MPI for Polymer Research, Max Planck Society;

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Zitation

Kulic, I. M., & Schiessel, H. (2003). Nucleosome repositioning via loop formation. Biophysical Journal, 84(5), 3197-3211.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-000F-6218-2
Zusammenfassung
Active (catalyzed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eukaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by earlier works. The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model-being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed, and compared to existing experimental findings.