de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Peripheral and Central Inputs Shape Network Dynamics in the Developing Visual Cortex In Vivo

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons39074

Siegel,  Friederike
Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society;
External Organizations;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38973

Lohmann,  Christian
Department: Cellular and Systems Neurobiology / Bonhoeffer, MPI of Neurobiology, Max Planck Society;
External Organizations;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Siegel, F., Heimel, J. A., Peters, J., & Lohmann, C. (2012). Peripheral and Central Inputs Shape Network Dynamics in the Developing Visual Cortex In Vivo. CURRENT BIOLOGY, 22(3), 253-258. doi:10.1016/j.cub.2011.12.026.


Cite as: http://hdl.handle.net/11858/00-001M-0000-000F-50C2-D
Abstract
Spontaneous network activity constitutes a central theme during the development of neuronal circuitry [1, 2]. Before the onset of vision, retinal neurons generate waves of spontaneous activity that are relayed along the ascending visual pathway [3, 4] and shape activity patterns in these regions [5, 6]. The spatiotemporal nature of retinal waves is required to establish precise functional maps in higher visual areas, and their disruption results in enlarged axonal projection areas (e.g., [7-10]). However, how retinal inputs shape network dynamics in the visual cortex on the cellular level is unknown. Using in vivo two-photon calcium imaging, we identified two independently occurring patterns of network activity in the mouse primary visual cortex (V1) before and at the onset of vision. Acute manipulations of spontaneous retinal activity revealed that one type of network activity largely originated in the retina and was characterized by low synchronicity (L-) events. In addition, we identified a type of high synchronicity (H-) events that required gap junction signaling but were independent of retinal input. Moreover, the patterns differed in wave progression and developmental profile. Our data suggest that different activity patterns have complementary functions during the formation of synaptic circuits in the developing visual cortex.