English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

A Rapid and Reliable Assay for Regioselectivity Using Fluorescence Spectroscopy

MPS-Authors
/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Angelovski, G., Keränen MD, Linnepe P, Grudzielanek, S., & Eilbracht, P. (2006). A Rapid and Reliable Assay for Regioselectivity Using Fluorescence Spectroscopy. Advanced Synthesis and Catalysis, 348(10-11), 1193-1199. doi:10.1002/adsc.200606047.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-D0C9-4
Abstract
The first report of a fluorescence-based assay for the direct measurement of the regioselectivity of a reaction is described herein, developed from the desire to construct a quicker analytical method for the determination of the ratio of regioisomers obtained in the tandem hydroformylation/Fischer indole synthesis. The method allows for extremely rapid acquisition times, as the use of crude reaction mixtures is allowed. The assay is also shown to be overall very reliable, tolerating the presence of various functional groups and proceeding on average with a standard error of measurement comparable to that of NMR. As fluorescence is the only requirement for the employment of this analytical method, countless numbers of target-specific assays can undoubtedly be developed based upon this initial finding.