English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  RAR gamma and Cdx1 interactions in vertebral patterning

Allan, D., Houle, M., Bouchard, N., Meyer, B., Gruss, P., & Lohnes, D. (2001). RAR gamma and Cdx1 interactions in vertebral patterning. Developmental Biology, 240(1), 46-60. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WDG-458PBJ6-4C-1&_cdi=6766&_user=38661&_pii=S0012160601904555&_origin=search&_coverDate=12%2F01%2F2001&_sk=997599998&view=c&wchp=dGLzVlz-zSkWb&md5=3ceceb2a70c01a6eb9c1a370ad5508e1&ie=/sdarticle.pdf.

Item is

Files

show Files
hide Files
:
16910.pdf (Publisher version), 0B
Name:
16910.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Allan, D., Author
Houle, M., Author
Bouchard, N., Author
Meyer, B.1, Author           
Gruss, P.1, Author           
Lohnes, D., Author
Affiliations:
1Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

Content

show
hide
Free keywords: retinoic acid receptor; Cdx1; vertebral patterning; somite; Hox; RARE
 Abstract: Exogenous retinoic acid (RA) can evoke vertebral homeosis when administered during late gastrulation. These vertebral transformations correlate with alterations of the rostral limit of Hox gene expression in the prevertebrae, suggesting that retinoid signaling regulates the combinatorial expression of Hox genes dictating vertebral identity. Conversely, loss of certain RA receptors (RARs) results in anterior homeotic transformations principally affecting the cervical region. Despite these observations, the relationship between retinoid signaling, somitic Hox expression, and vertebral patterning is poorly understood. The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are the homologues of Drosophila caudal and encode homeobox-containing transcription factors. Cdx1 homozygous null mutants exhibit anterior homeotic transformations, some of which are reminiscent of those in RAR gamma null offspring. in Cdx1 mutants, these transformations occur concomitant with posteriorized prevertebral expression of certain Hox genes. Cdx1 has recently been demonstrated to be a direct RA target, suggesting an indirect means by which retinoid signaling may impact vertebral patterning. To further investigate this relationship, a complete allelic series of Cdx1-RAR gamma mutants was generated and the skeletal phenotype assessed either following normal gestation or after administration of RA. Synergistic interactions between these null alleles were observed in compound mutants, and the full effects of exogenous RA on vertebral morphogenesis required Cdx1. These findings are consistent with a role for RA upstream of Cdx1 as regards axial patterning. However, exogenous RA attenuated several defects inherent to Cdx1 null mutants. This finding, together with the increased phenotypic severity of RAR gamma -Cdx1 double null mutants relative to single nulls, suggests that these pathways also function in parallel, likely by converging on common targets. (C) 2001 Academic Press.

Details

show
hide
Language(s):
 Dates: 2001-12-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Developmental Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 240 (1) Sequence Number: - Start / End Page: 46 - 60 Identifier: -