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  Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle

Majoul, I., Schmidt, T., Pomasanova, M., Boutkevich, E., Kozlov, Y., & Soeling, H. D. (2002). Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle. Journal of Cell Science, 115(4), 817-826. Retrieved from http://jcs.biologists.org/cgi/reprint/115/4/817.

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Majoul, I.1, Autor           
Schmidt, T., Autor
Pomasanova, M., Autor
Boutkevich, E.1, Autor           
Kozlov, Y., Autor
Soeling, H. D.1, Autor           
Affiliations:
1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Schlagwörter: AB5-toxins; glycosphingolipid receptors; cell cycle; Golgi
 Zusammenfassung: Cholera and Shiga toxin bind to the cell surface via glycolipid receptors GM1 and Gb3, respectively. Surprisingly, the majority of Vero cells from a non-synchronized population bind either Cholera or Shiga toxin but not both toxins. The hypothesis that the differential expression of toxin receptors is regulated by the cell cycle was tested. We find that Cholera toxin binds preferentially in G0/G1, with little binding through S-phase to telophase, whereas Shiga toxin binds maximally through G2 to telophase but does not bind during G0/G1 and S-phase. The changes result from the corresponding changes in Gb3 and GM1 synthesis, not from variations of receptor transport to the cell surface. The changes do not reflect competition of Gb3 and GM1 synthesis for lactosylceramide. Cells as diverse as Vero cells, PC12 cells and astrocytes show the same cell-cycle- dependent regulation of glycosphingolipid receptors, suggesting that this novel phenomenon is based on a conserved regulatory mechanism.

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Sprache(n): eng - English
 Datum: 2002-02-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 17129
URI: http://jcs.biologists.org/cgi/reprint/115/4/817
 Art des Abschluß: -

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Titel: Journal of Cell Science
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 115 (4) Artikelnummer: - Start- / Endseite: 817 - 826 Identifikator: -