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Free keywords:
Adenylate Cyclase/genetics/physiology; Animals; Calcium/physiology; Calmodulin/physiology; Gene Expression; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Mutant Strains; RNA, Messenger/genetics; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Retina/enzymology/growth & development/physiology; Signal Transduction/physiology; Superior Colliculus/enzymology/growth & development/physiology; Visual Pathways/growth & development/physiology
Abstract:
Development of the retino-collicular pathway has served as an important model system for examining the cellular mechanisms responsible for the establishment of neuronal maps of the sensory periphery. A consensus has emerged that molecular or chemical cues are responsible for the initial establishment of gross topography in this map, and that activity dependent factors sharpen this initial rough topography into precision. However, there is little evidence available concerning the biochemical signaling mechanisms that are responsible for topographic map refinement in the retino-collicular system. Using a combination of anatomical and biochemical techniques in normal and mutant mice, we provide evidence that Ca2+/Calmodulin regulated Adenylate Cyclase 1 (AC1), which is strongly expressed in the superficial layers of the colliculus, is an important downstream signaling agent for activity dependent map refinement in the superior colliculus.
