Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Dual lipolytic control of body fat storage and mobilization in Drosophila

Groenke, S., Mueller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., et al. (2007). Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biology, 5(6), 1248-1256. Retrieved from http://biology.plosjournals.org/perlserv/?request=get-pdf&file=10.1371_journal.pbio.0050137-S.pdf.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
316968.pdf (Verlagsversion), 0B
 
Datei-Permalink:
-
Name:
316968.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (UNKNOWN id 303; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Groenke, S.1, Autor           
Mueller, G., Autor
Hirsch, J., Autor
Fellert, S.1, Autor           
Andreou, A.1, Autor           
Haase, T., Autor
Jaeckle, H.1, Autor           
Kuehnlein, R. P.2, Autor           
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              
2Research Group of Molecular Physiology, MPI for biophysical chemistry, Max Planck Society, ou_578592              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ß-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2007-05-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: PLoS Biology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 5 (6) Artikelnummer: - Start- / Endseite: 1248 - 1256 Identifikator: -