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  Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging

Duda, P., Wojcicka, O., Wisniewski, J. R., & Rakus, D. (2018). Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging. Aging, 10(7), 1682-1697. doi:10.18632/aginh.101501.

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Duda et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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 Creators:
Duda, Przemyslaw1, Author
Wojcicka, Olga1, Author
Wisniewski, Jacek R.2, Author           
Rakus, Dariusz1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: METABOTROPIC GLUTAMATE RECEPTORS; MULTIENZYME DIGESTION FASP; LONG-TERM POTENTIATION; AGED RATS; ABSOLUTE QUANTIFICATION; POSITIVE INTERNEURONS; SYNAPTIC PLASTICITY; COGNITIVE FUNCTION; KAINATE RECEPTORS; NEURAL PLASTICITYCell Biology; Geriatrics & Gerontology; AMPA; GABA; NMDA; long-term potentiation; memory formation;
 Abstract: Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes at the protein level. Here, we present the deepest quantitative proteomic analysis of three brain regions, hippocampus, cortex and cerebellum, in mice aged 1 or 12 months, using the total protein approach technique. In all the brain regions, both in young and middle-aged animals, we quantitatively measured over 5,200 proteins. We found that although the total protein expression in middle-aged brain structures is practically unaffected by aging, there are significant differences between young and middle-aged mice in the expression of some receptors and signaling cascade proteins proven to be significant for learning and memory formation. Our analysis demonstrates that the hippocampus is the most variable structure during natural aging and that the first symptoms of weakening of neuronal plasticity may be observed on protein level in middle-aged animals.

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Language(s): eng - English
 Dates: 2018-072018
 Publication Status: Issued
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000440376500015
DOI: 10.18632/aginh.101501
 Degree: -

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Title: Aging
  Abbreviation : Aging (Albany NY)
Source Genre: Journal
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Publ. Info: New York : Impact Journals LLC
Pages: - Volume / Issue: 10 (7) Sequence Number: - Start / End Page: 1682 - 1697 Identifier: Other: 1945-4589
Other: http://www.sherpa.ac.uk/romeo/issn/1945-4589/
CoNE: https://pure.mpg.de/cone/journals/resource/1945-4589