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  Harmonic brain modes: A unifying framework for linking space and time in brain dynamics

Atasoy, S., Deco, G., Kringelbach, M. L., & Pearson, J. (2018). Harmonic brain modes: A unifying framework for linking space and time in brain dynamics. The Neuroscientist, 24(3), 277-293. doi:10.1177/1073858417728032.

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Genre: Zeitschriftenartikel

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 Urheber:
Atasoy, Selen 1, Autor
Deco, Gustavo1, 2, 3, 4, Autor           
Kringelbach, Morten L. 5, 6, Autor
Pearson, Joel 7, Autor
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Center for Music in the Brain, Aarhus University, Danmark, ou_persistent22              
7School of Psychology, University of New South Wales, Sydney, Australia, ou_persistent22              

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Schlagwörter: Resting state networks; Neural oscillations; Brain dynamics; Connectome harmonics; Sleep; Anesthesia; Psychedelics; Consciousness; Unifying framework
 Zusammenfassung: A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at “rest.” Here, we introduce the concept of harmonic brain modes—fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states (wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.

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Sprache(n): eng - English
 Datum: 2017-09-012018-06-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1177/1073858417728032
PMID: 28863720
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : BP-B 00270
Förderprogramm : Programa Beatriu de Pinos 2014
Förderorganisation : Generalitat de Catalunya
Projektname : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Projektname : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Förderprogramm : Funding Programme 7 (FP)
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : GNT1046198 ; GNT1085404
Förderprogramm : -
Förderorganisation : National Health and Medical Research Council (NHMRC)
Projektname : -
Grant ID : DP140101560 ; DP160103299
Förderprogramm : ARC Discovery Projects
Förderorganisation : National Health and Medical Research Council (NHMRC)
Projektname : -
Grant ID : GNT1049596
Förderprogramm : NHMRC Career Development Fellowship
Förderorganisation : National Health and Medical Research Council (NHMRC)

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Titel: The Neuroscientist
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Thousand Oaks, Calif. : Sage Publications, Inc.
Seiten: - Band / Heft: 24 (3) Artikelnummer: - Start- / Endseite: 277 - 293 Identifikator: ISSN: 1073-8584
CoNE: https://pure.mpg.de/cone/journals/resource/954928616245_1