English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells

van Dalen, R., De La Cruz Diaz, J. S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., et al. (2017). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv. doi:10.1101/238469.

Item is

Files

show Files
hide Files
:
Author Manuscript.pdf (Any fulltext), 403KB
 
File Permalink:
-
Name:
Author Manuscript.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
The copyright holder for this preprint is the author/funder. All rights reserved. No reuse allowed without permission.
License:
-

Locators

show
hide
Locator:
Preprint.pdf (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
van Dalen, Rob, Author
De La Cruz Diaz, Jacinto S., Author
Rumpret, Matevz, Author
Fuchsberger, Felix F.1, Author           
van Teijlingen, Nienke H., Author
Hanske, Jonas1, Author           
Rademacher, Christoph1, Author           
Geijtenbeek, Teunis B. H., Author
van Strip, Jos A. G., Author
Weidenmaier, Christopher, Author
Peschel, Andreas, Author
Kaplan, Daniel H., Author
van Sorge, Nina M., Author
Affiliations:
1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300              

Content

show
hide
Free keywords: -
 Abstract: Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD). Langerhans cells (LCs) initiate a Th17 response upon exposure to S. aureus, which contributes to host defense but also to AD pathogenesis. However, the molecular mechanisms underlying the unique pro-inflammatory capacities of S. aureus remain unclear. We demonstrate that human LCs directly interact with S. aureus through the pattern-recognition receptor langerin (CD207), which specifically recognizes the conserved β-N-acetylglucosamine (GlcNAc) modifications of wall teichoic acid (WTA) that are not expressed by other staphylococcal species. The WTA glycoprofile strongly influences the production of Th1- and Th17-polarizing cytokines by LCs. Specifically, β-GlcNAc activates LCs, whereas co-decoration of WTA with α-GlcNAc through the enzyme TarM, uniformly present in the AD-associated CC1 lineage, attenuates LC immune activation. Our findings provide important mechanistic insights into the role of S. aureus in inflammatory skin disease.

Details

show
hide
Language(s):
 Dates: 2017
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: bioRxiv
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -