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  Membrane fluctuations and acidosis regulate cooperative binding of “marker of self” CD47 with macrophage checkpoint receptor SIRPα

Steinkühler, J., Różycki, B., Alvey, C., Lipowsky, R., Weikl, T. R., Dimova, R., et al. (2019). Membrane fluctuations and acidosis regulate cooperative binding of “marker of self” CD47 with macrophage checkpoint receptor SIRPα. Journal of Cell Science, 132(4): JCS216770. doi:10.1242/jcs.216770.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-6109-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-73F0-4
Genre: Journal Article

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 Creators:
Steinkühler, Jan1, Author           
Różycki, Bartosz, Author
Alvey, Cory, Author
Lipowsky, Reinhard2, Author                 
Weikl, Thomas R.3, Author           
Dimova, Rumiana1, Author                 
Discher, Dennis E., Author
Affiliations:
1Rumiana Dimova, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863328              
2Reinhard Lipowsky, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863327              
3Thomas Weikl, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863330              

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 Abstract: Cell-cell interactions that result from membrane proteins binding weakly in trans can cause accumulations in cis that suggest cooperativity and thereby an acute sensitivity to environmental factors. The ubiquitous “marker of self” protein CD47 binds weakly to SIRPα on a macrophage, which leads to accumulation of SIRPα at a phagocytic synapse and ultimately to inhibition of engulfment of ‘self’ cells

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Language(s): eng - English
 Dates: 2018-05-182019
 Publication Status: Issued
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 Identifiers: DOI: 10.1242/jcs.216770
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Title: Journal of Cell Science
Source Genre: Journal
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Publ. Info: Cambridge, U.K. : The Company of Biologists Ltd
Pages: - Volume / Issue: 132 (4) Sequence Number: JCS216770 Start / End Page: - Identifier: ISSN: 0021-9533