Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals 
widespread loss of protein function

Hosp, Fabian; Gutiérrez-Ángel, Sara; Schaefer, Martin H.; Cox, Jürgen; Meissner, Felix; Hipp, Mark S.; Hartl, F. Ulrich; Klein, Rüdiger; Dudanova, Irina; Mann, Matthias

doi:10.1016/j.celrep.2017.10.097

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Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function

Hosp, F., Gutiérrez-Ángel, S., Schaefer, M. H., Cox, J., Meissner, F., Hipp, M. S., et al. (2017). Spatiotemporal proteomic profiling of Huntington’s disease inclusions reveals widespread loss of protein function. Cell Reports, 21(8), 2291-2303. doi:10.1016/j.celrep.2017.10.097.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-3B0D-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-AF3C-0

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Open Access funded by European Research Council

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https://www.sciencedirect.com/science/article/pii/S2211124717315772#app3 (Supplementary material) Open Access status unknown

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Data and Software Availability The accession number for the raw and processed data reported in this paper is PRIDE: PXD004973.

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Creators:
Hosp, Fabian¹, Author
Gutiérrez-Ángel, Sara², Author
Schaefer, Martin H., Author
Cox, Jürgen³, Author
Meissner, Felix⁴, Author
Hipp, Mark S.⁵, Author
Hartl, F. Ulrich⁵, Author
Klein, Rüdiger², Author
Dudanova, Irina², Author
Mann, Matthias¹, Author

Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159
2Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546
3Cox, Jürgen / Computational Systems Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_2063284
4Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678
5Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152

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Dates: Date issued: 2017-11-21

Publication Status: Issued

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Identifiers: DOI: 10.1016/j.celrep.2017.10.097

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Project name : Synergy grant “ToPAG—Toxic protein aggregation in neurodegeneration” (ERC-2012-SyG_318987-ToPAG)

Grant ID : 318987

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Funding organization : European Research Council

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Title: Cell Reports

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Publ. Info: Maryland Heights, MO : Cell Press

Pages: - Volume / Issue: 21 (8) Sequence Number: - Start / End Page: 2291 - 2303 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247