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  Peptide sharing between viruses and DLX proteins: A potential cross-reactivity pathway to neuropsychiatric disorders

Lucchese, G., & Stahl, B. (2018). Peptide sharing between viruses and DLX proteins: A potential cross-reactivity pathway to neuropsychiatric disorders. Frontiers in Neuroscience, 12: 150. doi:10.3389/fnins.2018.00150.

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Lucchese_Stahl_2017.pdf (Verlagsversion), 969KB
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 Urheber:
Lucchese, Guglielmo1, 2, Autor
Stahl, Benjamin2, 3, 4, 5, Autor           
Affiliations:
1Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany, ou_persistent22              
2Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
3Department of Neurology, Charité University Medicine Berlin, Berlin, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Psychologische Hochschule Berlin, Germany, ou_persistent22              

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Schlagwörter: Viral infections; Neuropsychiatric diseases; Language disorders; Fetal and adult neurogenesis; DLX proteins; Peptide sharing; Cross-reactivity; Autoimmunity
 Zusammenfassung: The present study seeks to determine potential associations between viral infections and neuropsychiatric diseases. To address this issue, we investigated the peptide commonalities between viruses that have been related to psychiatric and neurological disorders—such as rubella, human immunodeficiency virus, and herpesviruses—and human distal-less homeobox (DLX) proteins expressed in developing brain—namely, DLX1, DLX2, DLX5, and DLX6. Peptide matching analyses revealed a high degree of pentapeptide sharing. From an immunological perspective, this overlap is relevant because pentapeptides are endowed with immunogenicity and antigenicity—that is, they are immune determinants. Moreover, infection-induced immune cross-reactions might have functional, spatial, and temporal implications related to the functions and expression patterns of DLX1 and DLX5 in the fetal and adult human brain. In sum, our data support the hypothesis that viral infections may be linked to neuropsychiatric diseases through autoimmune cross-reactions caused by molecular mimicry between viral proteins and brain-specific DLX self-antigens.

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Sprache(n): eng - English
 Datum: 2017-06-242018-02-262018-03-21
 Publikationsstatus: Online veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3389/fnins.2018.00150
PMID: 29618965
PMC: PMC5871705
Anderer: eCollection 2018
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Förderorganisation : German Research Foundation (DFG)
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Förderprogramm : OpenAccess Publication Funds
Förderorganisation : Freie Universität Berlin

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Titel: Frontiers in Neuroscience
  Andere : Front Neurosci
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Lausanne, Switzerland : Frontiers Research Foundation
Seiten: - Band / Heft: 12 Artikelnummer: 150 Start- / Endseite: - Identifikator: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548