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  Regulation of methionine synthesis in Escherichia coli: Effect of metJ gene product and S-adenosylmethionine on the expression of the metF gene

Shoeman, R. L., Redfield, B., Coleman, T., Greene, R. C., Smith, A. A., Brot, N., et al. (1985). Regulation of methionine synthesis in Escherichia coli: Effect of metJ gene product and S-adenosylmethionine on the expression of the metF gene. Proceedings of the National Academy of Sciences of the United States of America, 82(11), 3601-3605. Retrieved from http://www.pnas.org/content/82/11/3601.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-CF11-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-CF12-3
Genre: Journal Article

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PNAS_82_1985_3601.pdf (Any fulltext), 986KB
 
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 Creators:
Shoeman, Robert L.1, 2, 3, Author           
Redfield, Betty, Author
Coleman, Timothy, Author
Greene, Ronald C., Author
Smith, Albert A., Author
Brot, Nathan, Author
Weissbach, Herbert, Author
Affiliations:
1Coherent diffractive imaging, Max Planck Institute for Medical Research, Max Planck Society, ou_1497692              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
3Analytical Protein Biochemistry, Max Planck Institute for Medical Research, Max Planck Society, ou_1497690              

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 Abstract: The regulation of the expression of the Escherichia coli metF gene, which codes for 5,10-methylenetet-rahydrofolate reductase (EC 1.1.99.15), has been investigated by using a simplified DNA-directed in vitro system that measures the formation of the first dipeptide (fMet-Ser) of the gene product. The synthesis of fMet-Ser directed by a plasmid containing the metF gene is specifically inhibited by metJ protein (repressor protein). S-Adenosylmethionine enhances the inhibition by the metJ protein of metF gene expression. The inhibition by the metJ protein is at the level of transcription and the results suggest that S-adenosylmethionine is functioning as an allosteric effector.

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Language(s): eng - English
 Dates: 1985-02-051985-06-011985-06-01
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: http://www.pnas.org/content/82/11/3601
URI: https://www.ncbi.nlm.nih.gov/pubmed/16593564
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 82 (11) Sequence Number: - Start / End Page: 3601 - 3605 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230