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  Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication

Senden, M., Reuter, N., van den Heuvel, M. P., Goebel, R., Deco, G., & Gilson, M. (2018). Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication. Human Brain Mapping, 39(3), 1246-1262. doi:10.1002/hbm.23913.

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https://onlinelibrary.wiley.com/doi/10.1002/hbm.23913 (Verlagsversion)
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 Urheber:
Senden, Mario1, 2, Autor
Reuter, Niels3, 4, Autor
van den Heuvel, Martijn P.5, Autor
Goebel, Rainer1, 2, 6, Autor
Deco, Gustavo7, 8, 9, 10, Autor           
Gilson, Matthieu7, Autor
Affiliations:
1Department of Cognitive Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
2Maastricht Brain Imaging Center (M-BIC), Maastricht University, the Netherlands, ou_persistent22              
3Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands, ou_persistent22              
6Department of Neuroimaging and Neuromodeling, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
7Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
8Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
9Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
10School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Schlagwörter: Computational modeling; Dynamics; Effective connectivity; fMRI; Network analysis; Resting state; Rich club; Task state
 Zusammenfassung: Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs—referred to as the rich club—has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity (EC) of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations. We find that the cortical rich club exhibits an increase in outgoing EC during task performance as compared with rest while incoming connectivity remains constant. Increased outgoing connectivity targets a sparse set of peripheral regions with specific regions strongly overlapping between tasks. At the same time, community detection analyses reveal massive reorganizations of interactions among peripheral regions, including those serving as target of increased rich club output. This suggests that while peripheral regions may play a role in several tasks, their concrete interplay might nonetheless be task-specific. Furthermore, we observe that whole-cortex dynamics are faster during task as compared with rest. The decoupling effects usually accompanying faster dynamics appear to be counteracted by the increased rich club outgoing EC. Together our findings speak to a gating mechanism of the rich club that supports fast-paced information exchange among relevant peripheral regions in a task-specific and goal-directed fashion, while constantly listening to the whole network.

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Sprache(n): eng - English
 Datum: 2017-11-232017-09-052017-11-302018-02-092018-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.23913
PMID: 29222818
Anderer: Epub 2017
 Art des Abschluß: -

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Projektinformation

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Projektname : Cracking the columnar-level code in the visual hierarchy: Ultra high-field functional MRI, neuro-cognitive modelling and high-resolution brain-computer interfaces / COLUMNARCODECRACKING
Grant ID : 269853
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Förderprogramm : Funding Programme 7 (FP7)
Förderorganisation : European Commission (EC)
Projektname : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Projektname : Biological neural networks: from structure to function / NeuArc2Fun
Grant ID : 656547
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : The Human Brain Project / HBP
Grant ID : 604102
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 452‐16‐015
Förderprogramm : -
Förderorganisation : Netherlands Organization for Scientific Research (NWO)

Quelle 1

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 39 (3) Artikelnummer: - Start- / Endseite: 1246 - 1262 Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686