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  Evidence of Resting-state Activity in Propofol-anesthetized Patients with Intracranial Tumors

Bisdas, S., Charyasz-Leks, E., Roder, C., Soares Tatagiba, M., Ernemann, U., & Klose, U. (2016). Evidence of Resting-state Activity in Propofol-anesthetized Patients with Intracranial Tumors. Academic Radiology, 23(2), 192-199. doi:10.1016/j.acra.2015.10.013.

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Bisdas, S, Autor
Charyasz-Leks, E1, 2, Autor           
Roder, C, Autor
Soares Tatagiba, M, Autor
Ernemann, U, Autor
Klose, U, Autor
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Zusammenfassung: Rationale and Objectives Resting-state (RS) networks, revealed by functional magnetic resonance imaging (fMRI) studies in healthy volunteers, have never been evaluated in anesthetized patients with brain tumors. Our purpose was to examine the presence of residual brain activity on the auditory network during propofol-induced loss of consciousness in patients with brain tumors. Materials and Methods Twenty subjects with intracranial masses were prospectively studied by means of intraoperative RS-fMRI acquisitions before any craniectomy. After performing single-subject independent component analysis, spatial maps and time courses were assigned to an auditory RS network template from the literature and compared via spatial regression coefficients. Results All fMRI data were of sufficient quality for further postprocessing. In all but two patients, the RS functional activity of the auditory network could be successfully mapped. In almost all patients, contralateral activation of the auditory network was present. No significant difference was found between the mean distance of the RS activity clusters and the lesion periphery for tumors located in the temporal gyri vs. those in other brain regions. The spatial deviation between the activated cluster in our experiment and the template was significantly (P = 0.04) higher in patients with tumors located in the temporal gyri than in patients with tumors located in other regions. Conclusions Propofol-induced anesthesia in patients with intracranial lesions does not alter the blood-oxygenation level-depended signal, and independent component analysis of intraoperative RS-fMRI may allow assessment of the auditory network in a clinical setting.

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 Datum: 2016-06
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1016/j.acra.2015.10.013
BibTex Citekey: BisdasCRSEK2016
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Titel: Academic Radiology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 23 (2) Artikelnummer: - Start- / Endseite: 192 - 199 Identifikator: -