English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

Chheda, Z. S., Kohanbash, G., Okada, K., Jahan, N., Sidney, J., Pecoraro, M., et al. (2018). Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. Journal of Experimental Medicine, 215(1), 141-157. doi:10.1084/jem.20171046.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0000-74CE-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-74CF-5
Genre: Journal Article

Files

show Files
hide Files
:
141.full.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
141.full.pdf
Description:
-
OA-Status:
Visibility:
Restricted (embargoed till 2018-06-01) (Max Planck Institute of Biochemistry, MMBC; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2018 Chheda et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
License:
https://creativecommons.org/licenses/by-nc-sa/4.0/
:
JEM_20171046_sm.pdf (Supplementary material), 473KB
 
File Permalink:
-
Name:
JEM_20171046_sm.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Biochemistry, MMBC; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Chheda, Zinal S.1, Author
Kohanbash, Gary1, Author
Okada, Kaori1, Author
Jahan, Naznin1, Author
Sidney, John1, Author
Pecoraro, Matteo2, Author           
Yang, Xinbo1, Author
Carrera, Diego A.1, Author
Downey, Kira M.1, Author
Shrivastav, Shruti1, Author
Liu, Shuming1, Author
Lin, Yi1, Author
Lagisetti, Chetana1, Author
Chuntova, Pavlina1, Author
Watchmaker, Payal B.1, Author
Mueller, Sabine1, Author
Pollack, Ian F.1, Author
Rajalingam, Raja1, Author
Carcaboso, Angel M.1, Author
Mann, Matthias2, Author           
Sette, Alessandro1, AuthorGarcia, K. Christopher1, AuthorHou, Yafei1, AuthorOkada, Hideho1, Author more..
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Content

show
hide
Free keywords: CENTRAL-NERVOUS-SYSTEM; ALTERED PEPTIDE LIGANDS; TCR GENE-THERAPY; CANCER REGRESSION; PONTINE GLIOMAS; ANTIGEN; CTL; IDENTIFICATION; GLIOBLASTOMA; EXPRESSIONImmunology; Research & Experimental Medicine;
 Abstract: The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). From a CD8(+) T cell clone established by stimulation of HLA-A2(+) CD8(+) T cells with synthetic peptide encompassing the H3.3K27M mutation, complementary DNA for T cell receptor (TCR) alpha- and beta-chains were cloned into a retroviral vector. TCR -transduced HLA-A2(+) T cells efficiently killed HLA-A2(+)H3.3K27M(+) glioma cells in an antigen- and HLA-specific manner. Adoptive transfer of TCR -transduced T cells significantly suppressed the progression of glioma xenografts in mice. Alanine-scanning assays suggested the absence of known human proteins sharing the key amino acid residues required for recognition by the TCR, suggesting that the TCR could be safely used in patients. These data provide us with a strong basis for developing T cell-based therapy targeting this shared neoepitope.

Details

show
hide
Language(s): eng - English
 Dates: 2017-12-042018-01-02
 Publication Status: Issued
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000419134400013
DOI: 10.1084/jem.20171046
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Experimental Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, Md. : Rockefeller Institute for Medical Research
Pages: - Volume / Issue: 215 (1) Sequence Number: - Start / End Page: 141 - 157 Identifier: ISSN: 0022-1007
CoNE: https://pure.mpg.de/cone/journals/resource/954925413886