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  Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states

Deco, G., Cabral, J., Saenger, V. M., Boly, M., Tagliazucchi, E., Laufs, H., et al. (2018). Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states. NeuroImage, 169, 46-56. doi:10.1016/j.neuroimage.2017.12.009.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-98D9-A Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-51C5-1
Genre: Zeitschriftenartikel

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Urheber

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 Urheber:
Deco, Gustavo1, 2, 3, 4, Autor           
Cabral, Joana5, 6, 7, Autor
Saenger, Victor M.1, Autor
Boly, Melanie8, 9, Autor
Tagliazucchi, Enzo10, 11, Autor
Laufs, Helmut11, 12, Autor
Van Someren, Eus13, 14, Autor
Jobst, Beatrice1, Autor
Stevner, Angus5, 6, Autor
Kringelbach, Morten L.5, 6, 7, 15, Autor
Affiliations:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Center for Music in the Brain, Aarhus University, the Netherlands, ou_persistent22              
7ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
8Department of Psychiatry, University of Wisconsin, Madison, WI, USA, ou_persistent22              
9Department of Neurology, University of Wisconsin, Madison, WI, USA, ou_persistent22              
10Institute for Medical Psychology, Christian Albrecht University Kiel, Germany, ou_persistent22              
11Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
12Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
13Department of Sleep and Cognition, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
14Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
15Institut d’études avancées de Paris, France, ou_persistent22              

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Schlagwörter: Brain state; Sleep; Whole brain modeling; Perturbation
 Zusammenfassung: Human neuroimaging research has revealed that wakefulness and sleep involve very different activity patterns. Yet, it is not clear why brain states differ in their dynamical complexity, e.g. in the level of integration and segregation across brain networks over time. Here, we investigate the mechanisms underlying the dynamical stability of brain states using a novel off-line in silico perturbation protocol. We first adjust a whole-brain computational model to the basal dynamics of wakefulness and deep sleep recorded with fMRI in two independent human fMRI datasets. Then, the models of sleep and awake brain states are perturbed using two distinct multifocal protocols either promoting or disrupting synchronization in randomly selected brain areas. Once perturbation is halted, we use a novel measure, the Perturbative Integration Latency Index (PILI), to evaluate the recovery back to baseline. We find a clear distinction between models, consistently showing larger PILI in wakefulness than in deep sleep, corroborating previous experimental findings. In the models, larger recoveries are associated to a critical slowing down induced by a shift in the model's operation point, indicating that the awake brain operates further from a stable equilibrium than deep sleep. This novel approach opens up for a new level of artificial perturbative studies unconstrained by ethical limitations allowing for a deeper investigation of the dynamical properties of different brain states.

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Sprache(n): eng - English
 Datum: 2017-11-272017-06-012017-12-042017-12-072018-04-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.neuroimage.2017.12.009
PMID: 29225066
Anderer: Epub 2017
 Art des Abschluß: -

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Projektinformation

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Projektname : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : Brain-inspired multiscale computation in neuromorphic hybrid systems / BRAINSCALES
Grant ID : 269921
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : DNRF117
Förderprogramm : -
Förderorganisation : Danish National Research Foundation
Projektname : Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases
Grant ID : NORTE-01-0145-FEDER-000023
Förderprogramm : Northern Portugal Regional Operational Programme (NORTE 2020)
Förderorganisation : CCDR-N
Projektname : -
Grant ID : -
Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)

Quelle 1

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 169 Artikelnummer: - Start- / Endseite: 46 - 56 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166