Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo

Kim, T., Oh, W. C., Choi, J. H., & Kwon, H.-B. (2016). Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo. Proceedings of the National Academy of Sciences, 113(10), 1372-1381. doi:10.1073/pnas.1513410113.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel
Alternativer Titel : Proceedings of the National Academy of Sciences

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kim, Taekeun1, Autor
Oh, Won Chan1, Autor
Choi, Joon Ho1, Autor
Kwon, Hyung-Bae1, 2, Autor
Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288              
2MPI of Neurobiology, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_1110547              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: During cortical circuit development in the mammalian brain, groups of excitatory neurons that receive similar sensory information form microcircuits. However, cellular mechanisms underlying cortical microcircuit development remain poorly understood. Here we implemented combined two-photon imaging and photolysis in vivo to monitor and manipulate neuronal activities to study the processes underlying activity-dependent circuit changes. We found that repeated triggering of spike trains in a randomly chosen group of layer 2/3 pyramidal neurons in the somatosensory cortex triggered long-term plasticity of circuits (LTPc), resulting in the increased probability that the selected neurons would fire when action potentials of individual neurons in the group were evoked. Significant firing pattern changes were observed more frequently in the selected group of neurons than in neighboring control neurons, and the induction was dependent on the time interval between spikes, N-methyl-D-aspartate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activation. In addition, LTPc was associated with an increase of activity from a portion of neighboring neurons with different probabilities. Thus, our results demonstrate that the formation of functional microcircuits requires broad network changes and that its directionality is nonrandom, which may be a general feature of cortical circuit assembly in the mammalian cortex.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2016
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Proceedings of the National Academy of Sciences
  Alternativer Titel : Proceedings of the National Academy of Sciences
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 113 (10) Artikelnummer: - Start- / Endseite: 1372 - 1381 Identifikator: -