Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In 
Vivo

Villa, Katherine L.; Berry, Kalen P.; Subramanian, Jaichandar; Cha, Jae Won; Oh, Won Chan; Kwon, Hyung-Bae; Kubota, Yoshiyuki; So, Peter T. C.; Nedivi, Elly

doi:10.1016/j.neuron.2016.01.010

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Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo

Villa, K. L., Berry, K. P., Subramanian, J., Cha, J. W., Oh, W. C., Kwon, H.-B., et al. (2016). Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo. Neuron, 89(4), 756-769. doi:10.1016/j.neuron.2016.01.010.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-2C81-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-2C90-E

Genre: Journal Article

Alternative Title : Neuron

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Villa, Katherine L.¹, Author
Berry, Kalen P.¹, Author
Subramanian, Jaichandar¹, Author
Cha, Jae Won¹, Author
Oh, Won Chan², Author
Kwon, Hyung-Bae^{2, 3}, Author
Kubota, Yoshiyuki¹, Author
So, Peter T. C.¹, Author
Nedivi, Elly¹, Author

Affiliations:
1External Organizations, ou_persistent22
2Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288
3MPI of Neurobiology, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_1110547

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Abstract: Older concepts of a hard-wired adult brain have been overturned in recent years by in vivo imaging studies revealing synaptic remodeling, now thought to mediate rearrangements in microcircuit connectivity. Using three-color labeling and spectrally resolved two-photon microscopy, we monitor in parallel the daily structural dynamics (assembly or removal) of excitatory and inhibitory postsynaptic sites on the same neurons in mouse visual cortex in vivo. We find that dynamic inhibitory synapses often disappear and reappear again in the same location. The starkest contrast between excitatory and inhibitory synapse dynamics is on dually innervated spines, where inhibitory synapses frequently recur while excitatory synapses are stable. Monocular deprivation, a model of sensory input-dependent plasticity, shortens inhibitory synapse lifetimes and lengthens intervals to recurrence, resulting in a new dynamic state with reduced inhibitory synaptic presence. Reversible structural dynamics indicate a fundamentally new role for inhibitory synaptic remodeling-flexible, input-specific modulation of stable excitatory connections.

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Dates: Date issued: 2016

Publication Status: Issued

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Identifiers: URI: http://www.ncbi.nlm.nih.gov/pubmed/26853302
DOI: 10.1016/j.neuron.2016.01.010

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Title: Neuron

Alternative Title : Neuron

Source Genre: Journal

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Pages: - Volume / Issue: 89 (4) Sequence Number: - Start / End Page: 756 - 769 Identifier: ISBN: 1097-4199