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  Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence

Beylergil, S. B., Beck, A., Deserno, L., Lorenz, R. C., Rapp, M. A., Schlagenhauf, F., et al. (2017). Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence. NeuroImage: Clinical, 15, 80-94. doi:10.1016/j.nicl.2017.04.010.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-FD6D-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C6E3-D
Genre: Journal Article

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 Creators:
Beylergil, Sinem Balta1, 2, Author
Beck, Anne3, Author
Deserno, Lorenz3, 4, 5, Author           
Lorenz, Robert C.3, 6, Author
Rapp, Michael A.7, Author
Schlagenhauf, Florian3, 4, Author           
Heinz, Andreas3, 8, Author
Obermayer, Klaus1, 2, Author
Affiliations:
1Department of Software Engineering and Theoretical Computer Science, TU Berlin, Germany, ou_persistent22              
2Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
7Department of Social and Preventive Medicine, University of Potsdam, Germany, ou_persistent22              
8NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Alcohol dependence; Prediction error; Reinforcement learning; Reversal learning; Dorsolateral prefrontal cortex; Decision-making
 Abstract: Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the "double-update" model, which assumes that subjects infer the knowledge that reward contingencies are anticorrelated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.

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Language(s): eng - English
 Dates: 2017-03-242016-12-232017-04-142017-04-17
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nicl.2017.04.010
PMID: 28491495
PMC: PMC5413198
Other: eCollection 2017
 Degree: -

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Project name : “Sensory Computation in Neural Systems” / GRK 1589/1
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : NeuroCure - neue Perspektiven in der Therapie neurologischer Erkrankungen / EXC 257
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Lern- und Gewöhnungsprozesse als Prädiktoren für die Entwicklung und Aufrechterhaltung alkoholbezogener Störungen / FOR 1617
Grant ID : HE2597/14-1 ; HE2597/14-2
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : SCHL 1968/1-1 ; SCHL 1969/1-1 ; SCHL 1969/2-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : e:Med: Med Alcohol Addiction - A Systems-Oriented Approach
Grant ID : 01ZX1311E ; 01ZX1611E ; 01EE1406A
Funding program : -
Funding organization : German Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : RA 1047/2-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : 01ET1001A ; 01GQ0914
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

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Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 15 Sequence Number: - Start / End Page: 80 - 94 Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582