English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  1H, 13C and 15N resonance assignment of human guanylate kinase.

Khan, N., Ban, D., Trigo-Mourino, P., Carneiro, M. G., Konrad, M., Lee, D., et al. (2018). 1H, 13C and 15N resonance assignment of human guanylate kinase. Biomolecular NMR Assignments, 12(1), 11-14. doi:10.1007/s12104-017-9771-6.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-E41D-B Version Permalink: https://hdl.handle.net/21.11116/0000-0003-74B2-1
Genre: Journal Article

Files

show Files
hide Files
:
2478856.pdf (Publisher version), 893KB
 
File Permalink:
-
Name:
2478856.pdf
Description:
-
OA-Status:
Visibility:
Restricted ( Max Planck Society (every institute); )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Khan, N.1, Author           
Ban, D., Author
Trigo-Mourino, P.2, Author           
Carneiro, M. G.2, Author           
Konrad, M.1, Author           
Lee, D.2, Author           
Sabo, T. M.2, Author           
Affiliations:
1Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578612              
2Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              

Content

show
hide
Free keywords: Enzyme; Guanylate kinase (GMPK); NMR assignment; Nucleotide kinase
 Abstract: Human guanylate kinase (hGMPK) is a critical enzyme that, in addition to phosphorylating its physiological substrate (d)GMP, catalyzes the second phosphorylation step in the conversion of anti-viral and anti-cancer nucleoside analogs to their corresponding active nucleoside analog triphosphates. Until now, a high-resolution structure of hGMPK is unavailable and thus, we studied free hGMPK by NMR and assigned the chemical shift resonances of backbone and side chain 1H, 13C, and 15N nuclei as a first step towards the enzyme's structural and mechanistic analysis with atomic resolution.

Details

show
hide
Language(s): eng - English
 Dates: 2017-08-312018-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s12104-017-9771-6
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biomolecular NMR Assignments
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 (1) Sequence Number: - Start / End Page: 11 - 14 Identifier: -