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  Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue

Boccia, E., Luther, S., & Parlitz, U. (2017). Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 375(2102): 20160289. doi:10.1098/rsta.2016.0289.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-C955-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2F17-2
Genre: Journal Article

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 Creators:
Boccia, Edda1, Author              
Luther, Stefan1, Author              
Parlitz, Ulrich1, Author              
Affiliations:
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, escidoc:2063288              

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Free keywords: excitable media, anisotropy, cardiac dynamics, virtual electrodes, vulnerable window, defibrillation
 Abstract: In cardiac tissue, electrical spiral waves pinned to a heterogeneity can be unpinned (and eventually terminated) using electric far field pulses and recruiting the heterogeneity as a virtual electrode. While for isotropic media the process of unpinning is much better understood, the case of an anisotropic substrate with different conductivities in different directions still needs intensive investigation. To study the impact of anisotropy on the unpinning process, we present numerical simulations based on the bidomain formulation of the phase I of the Luo and Rudy action potential model modified due to the occurrence of acute myocardial ischaemia. Simulating a rotating spiral wave pinned to an ischaemic heterogeneity, we compare the success of sequences of far field pulses in the isotropic and the anisotropic case for spirals still in transient or in steady rotation states. Our results clearly indicate that the range of pacing parameters resulting in successful termination of pinned spiral waves is larger in anisotropic tissue than in an isotropic medium. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’.

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Language(s): eng - English
 Dates: 2017-05-152017-09-13
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1098/rsta.2016.0289
 Degree: -

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Title: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 375 (2102) Sequence Number: 20160289 Start / End Page: - Identifier: -