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  Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

Bröker‐Lai, J., Kollewe, A., Schindeldecker, B., Pohle, J., Chi, V. N., Mathar, I., et al. (2017). Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. The EMBO Journal, 36(18): e201696369, pp. 2770-2789. doi:10.15252/embj.201696369.

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 Urheber:
Bröker‐Lai, Jenny, Autor
Kollewe, Astrid, Autor
Schindeldecker, Barbara, Autor
Pohle, Jörg, Autor
Chi, Vivan Nguyen, Autor
Mathar, Ilka, Autor
Guzman, Raul, Autor
Schwarz, Yvonne, Autor
Lai, Alan, Autor
Weißgerber, Petra, Autor
Schwegler, Herbert, Autor
Dietrich, Alexander, Autor
Both, Martin, Autor
Sprengel, Rolf1, Autor           
Draguhn, Andreas, Autor
Köhr, Georg, Autor
Fakler, Bernd, Autor
Flockerzi, Veit, Autor
Bruns, Dieter, Autor
Freichel, Marc, Autor
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Schlagwörter: cross-frequency coupling; hippocampal synaptic transmission; relearning; spatial working memory; TRPC1/C4/C5 heteromeric assembly
 Zusammenfassung: Canonical transient receptor potential (TRPC) channels influence various neuronal functions. Using quantitative high-resolution mass spectrometry, we demonstrate that TRPC1, TRPC4, and TRPC5 assemble into heteromultimers with each other, but not with other TRP family members in the mouse brain and hippocampus. In hippocampal neurons from Trpc1/Trpc4/Trpc5-triple-knockout (Trpc1/4/5-/-) mice, lacking any TRPC1-, TRPC4-, or TRPC5-containing channels, action potential-triggered excitatory postsynaptic currents (EPSCs) were significantly reduced, whereas frequency, amplitude, and kinetics of quantal miniature EPSC signaling remained unchanged. Likewise, evoked postsynaptic responses in hippocampal slice recordings and transient potentiation after tetanic stimulation were decreased. In vivo, Trpc1/4/5-/- mice displayed impaired cross-frequency coupling in hippocampal networks and deficits in spatial working memory, while spatial reference memory was unaltered. Trpc1/4/5-/- animals also exhibited deficiencies in adapting to a new challenge in a relearning task. Our results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.

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Sprache(n): eng - English
 Datum: 2017-07-012016-12-222017-07-072017-08-082017
 Publikationsstatus: Erschienen
 Seiten: 20
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
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Titel: The EMBO Journal
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Nature Publishing Group
Seiten: - Band / Heft: 36 (18) Artikelnummer: e201696369 Start- / Endseite: 2770 - 2789 Identifikator: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1