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  Social network architecture of human immune cells unveiled by quantitative proteomics

Rieckmann, J. C., Geiger, R., Hornburg, D., Wolf, T., Kveler, K., Jarrossay, D., et al. (2017). Social network architecture of human immune cells unveiled by quantitative proteomics. Nature Immunology, 18(5), 583-593. doi:10.1038/ni.3693.

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 Creators:
Rieckmann, Jan C.1, Author           
Geiger, Roger2, Author
Hornburg, Daniel1, Author           
Wolf, Tobias2, Author
Kveler, Ksenya2, Author
Jarrossay, David2, Author
Sallusto, Federica2, Author
Shen-Orr, Shai S.2, Author
Lanzavecchia, Antonio2, Author
Mann, Matthias1, Author           
Meissner, Felix3, Author           
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
2external, ou_persistent22              
3Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149678              

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Free keywords: NATURAL-KILLER-CELLS; CD8(+) T-CELLS; GENE-EXPRESSION; QUANTIFICATION; SYSTEM; RESPONSESImmunology;
 Abstract: The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology.

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Language(s): eng - English
 Dates: 2017-03-062017
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000399378700015
DOI: 10.1038/ni.3693
 Degree: -

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Title: Nature Immunology
  Other : Nat. Immunol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 18 (5) Sequence Number: - Start / End Page: 583 - 593 Identifier: ISSN: 1529-2908
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073