English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Resonance Raman study of the cytochrome P-450 LM2-halothane intermediate complex.

Hildebrandt, P., Garda, H., Stier, A., Stockburger, M., & Van Dyke, R. A. (1988). Resonance Raman study of the cytochrome P-450 LM2-halothane intermediate complex. FEBS Letters, 237(1-2), 15-20.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hildebrandt, P.1, Author           
Garda, H., Author
Stier, A.1, Author           
Stockburger, M.1, Author           
Van Dyke, R. A., Author
Affiliations:
1Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society, ou_578624              

Content

show
hide
Free keywords: -
 Abstract: Resonance Raman (RR) and absorption spectroscopic studies of purified rabbit liver cytochromes P-450 show that the form 2 isomer (LM2) but not the form 4 isomer (LM4) forms a long-lived complex with halothane after dithionite reduction, absorbing light at 470 nm, in which ferric 6-coordinated heme iron in the low-spin configuration is liganded to 2-chloro-1,1-difluoroethylene. The RR data exclude the possibility that the CF3CHCl− carbanion is a ligand and are consistent with the involvement of an active-site pocket in the cytochrome P-450 polypeptide.

Details

show
hide
Language(s): eng - English
 Dates: 1988-09-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: FEBS Letters
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 237 (1-2) Sequence Number: - Start / End Page: 15 - 20 Identifier: -