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  Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?

Huber, E., Lachapelle, P., Sutter, R., Curt, A., & Freund, P. (2017). Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury? Annals of Neurology, 81(5), 740-748. doi:10.1002/ana.24932.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-25F1-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-4D38-7
Genre: Zeitschriftenartikel

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 Urheber:
Huber, Eveline1, Autor
Lachapelle, Patrice1, Autor
Sutter, Reto2, Autor
Curt, Armin1, Autor
Freund, Patrick1, 3, 4, 5, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Radiology, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
4Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Schlagwörter: Midsagittal tissue bridges; Recovery; Spinal cord injury
 Zusammenfassung: T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At one month post-injury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at one month post-injury were associated with neurological and functional recovery at 1 year follow-up. Neuroimaging biomarkers of lesion area and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials.

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Sprache(n): eng - English
 Datum: 2016-09-282017-04-042017-04-102017-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/ana.24932
PMID: 28393423
 Art des Abschluß: -

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Projektinformation

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Projektname : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : Clinical Research Priority Program (CRPP)
Förderorganisation : University Zurich
Projektname : -
Grant ID : WFL‐CH‐007/14
Förderprogramm : -
Förderorganisation : Wings for Life, Austria

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Titel: Annals of Neurology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Boston : American Neurological Association
Seiten: - Band / Heft: 81 (5) Artikelnummer: - Start- / Endseite: 740 - 748 Identifikator: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748