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  Engineering fatty acid synthases for directed polyketide production.

Gajewski, J., Buelens, F. P., Serdjukow, S., Janßen, M., Cortina, N., Grubmüller, H., et al. (2017). Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology, 13(4), 363-365. doi:10.1038/nchembio.2314.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-8359-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-21AB-9
Genre: Journal Article

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 Creators:
Gajewski, J., Author
Buelens, F. P.1, Author           
Serdjukow, S., Author
Janßen, M., Author
Cortina, N., Author
Grubmüller, H.1, Author           
Grininger, M., Author
Affiliations:
1Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578631              

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 Abstract: In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.

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Language(s): eng - English
 Dates: 2017-02-202017-04
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nchembio.2314
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Title: Nature Chemical Biology
Source Genre: Journal
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Pages: - Volume / Issue: 13 (4) Sequence Number: - Start / End Page: 363 - 365 Identifier: -