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  Optical control of GIRK channels using visible light

Trads, J. B., Burgstaller, J., Laprell, L., Konrad, D. B., de la Osa de la Rosa, L., Weaver, C. D., et al. (2017). Optical control of GIRK channels using visible light. Organic & Biomolecular Chemistry, 15(1), 76-81. doi:10.1039/c6ob02153k.

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 Urheber:
Trads, Julie B., Autor
Burgstaller, Jessica1, Autor           
Laprell, Laura, Autor
Konrad, David B., Autor
de la Osa de la Rosa, Luis, Autor
Weaver, C. David, Autor
Baier, Herwig1, Autor           
Trauner, Dirk, Autor
Barber, David M., Autor
Affiliations:
1Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Schlagwörter: RECTIFYING POTASSIUM CHANNELS; AZOBENZENE PHOTOSWITCHES; PHOTODYNAMIC THERAPY; GLUTAMATE-RECEPTOR; NEURONAL-ACTIVITY; MAMMALIAN-CELLS; REMOTE-CONTROL; IN-VIVO; PHOTOPHARMACOLOGY; SWITCHESChemistry;
 Zusammenfassung: G-protein coupled inwardly rectifying potassium (GIRK) channels are an integral part of inhibitory signal transduction pathways, reducing the activity of excitable cells via hyperpolarization. They play crucial roles in processes such as cardiac output, cognition and the coordination of movement. Therefore, the precision control of GIRK channels is of critical importance. Here, we describe the development of the azobenzene containing molecule VLOGO (Visible Light Operated GIRK channel Opener), which activates GIRK channels in the dark and is promptly deactivated when illuminated with green light. VLOGO is a valuable addition to the existing tools for the optical control of GIRK channels as it circumvents the need to use potentially harmful UV irradiation. We therefore believe that VLOGO will be a useful research tool for studying GIRK channels in biological systems.

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Sprache(n): eng - English
 Datum: 2017-01-07
 Publikationsstatus: Erschienen
 Seiten: 6
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000391698600009
DOI: 10.1039/c6ob02153k
 Art des Abschluß: -

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Titel: Organic & Biomolecular Chemistry
  Andere : Organic and Biomolecular Chemistry
  Kurztitel : Org. Biomol. Chem.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge : Royal Society of Chemistry
Seiten: - Band / Heft: 15 (1) Artikelnummer: - Start- / Endseite: 76 - 81 Identifikator: ISSN: 1477-0520
CoNE: https://pure.mpg.de/cone/journals/resource/954925269322