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  Time lapse in vivo visualization of developmental stabilization of synaptic receptors at Neuromuscular Junctions

Yampolsky, P., Pacifici, P. G., Lomb, L., Giese, G., Rudolf, R., Roeder, I. V., et al. (2010). Time lapse in vivo visualization of developmental stabilization of synaptic receptors at Neuromuscular Junctions. The Journal of Biological Chemistry, 285(45), 34589-34596. doi:10.1074/jbc.M110.168880.

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Alternativer Titel : Time lapse in vivo visualization of developmental stabilization of synaptic receptors at Neuromuscular Junctions

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 Urheber:
Yampolsky, Pessah1, Autor           
Pacifici, Pier Giorgio1, Autor           
Lomb, Lukas2, Autor           
Giese, Günter3, Autor           
Rudolf, Rüdiger, Autor
Roeder, Ira V., Autor
Witzemann, Veit1, Autor           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              
3Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Zusammenfassung: The lifetime of nicotinic acetylcholine receptors (AChRs) in neuromuscular junctions (NMJs) is increased from <1 day to >1 week during early postnatal development. However, the exact timing of AChR stabilization is not known, and its correlation to the concurrent embryonic to adult AChR channel conversion, NMJ remodeling, and neuromuscular diseases is unclear. Using a novel time lapse in vivo imaging technology we show that replacement of the entire receptor population of an individual NMJ occurs end plate-specifically within hours. This makes it possible to follow directly in live animals changing stabilities of end plate receptors. In three different, genetically modified mouse models we demonstrate that the metabolic half-life values of synaptic AChRs increase from a few hours to several days after postnatal day 6. Developmental stabilization is independent of receptor subtype and apparently regulated by an intrinsic muscle-specific maturation program. Myosin Va, an F-actin-dependent motor protein, is also accumulated synaptically during postnatal development and thus could mediate the stabilization of end plate AChR.

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Sprache(n): eng - English
 Datum: 2010-07-272010-09-022010-09-022010-11-05
 Publikationsstatus: Erschienen
 Seiten: 8
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 664581
DOI: 10.1074/jbc.M110.168880
URI: http://www.ncbi.nlm.nih.gov/pubmed/20813841
Anderer: 7605
 Art des Abschluß: -

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Titel: The Journal of Biological Chemistry
  Andere : JBC
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Baltimore, etc. : American Society for Biochemistry and Molecular Biology [etc.]
Seiten: - Band / Heft: 285 (45) Artikelnummer: - Start- / Endseite: 34589 - 34596 Identifikator: ISSN: 0021-9258
CoNE: https://pure.mpg.de/cone/journals/resource/954925410826_1