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  MEG-measured visually induced gamma-band oscillations in chronic schizophrenia: Evidence for impaired generation of rhythmic activity in ventral stream regions

Grent-'t-Jong, T., Rivolta, D., Sauer, A., Grube, M., Singer, W., Wibral, M., et al. (2016). MEG-measured visually induced gamma-band oscillations in chronic schizophrenia: Evidence for impaired generation of rhythmic activity in ventral stream regions. Schizophrenia Research, 176(2-3), 177-185. doi:10.1016/j.schres.2016.06.003.

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 Creators:
Grent-'t-Jong, Tineke, Author
Rivolta, Davide1, 2, Author
Sauer, Andreas1, 2, Author
Grube, Michael, Author
Singer, Wolf1, 2, Author                 
Wibral, Michael, Author
Uhlhaas, Peter J.1, 2, Author
Affiliations:
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstr. 46, 60528 Frankfurt, DE, ou_2074314              
2Singer Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt, DE, ou_3381220              

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Free keywords: Adult Alpha Rhythm Brain/*physiopathology Chronic Disease Female *Gamma Rhythm Humans *Magnetoencephalography Male Motion Perception/*physiology Neuropsychological Tests Psychiatric Status Rating Scales Reaction Time Schizophrenia/*physiopathology Signal Processing, Computer-Assisted *E/I-balance *meg *Oscillations *Schizophrenia *Ventral stream *Visual cortex
 Abstract: BACKGROUND: Gamma-band oscillations are prominently impaired in schizophrenia, but the nature of the deficit and relationship to perceptual processes is unclear. METHODS: 16 patients with chronic schizophrenia (ScZ) and 16 age-matched healthy controls completed a visual paradigm while magnetoencephalographic (MEG) data was recorded. Participants had to detect randomly occurring stimulus acceleration while viewing a concentric moving grating. MEG data were analyzed for spectral power (1-100Hz) at sensor- and source-level to examine the brain regions involved in aberrant rhythmic activity, and for contribution of differences in baseline activity towards the generation of low- and high-frequency power. RESULTS: Our data show reduced gamma-band power at sensor level in schizophrenia patients during stimulus processing while alpha-band and baseline spectrum were intact. Differences in oscillatory activity correlated with reduced behavioral detection rates in the schizophrenia group and higher scores on the "Cognitive Factor" of the Positive and Negative Syndrome Scale. Source reconstruction revealed that extra-striate (fusiform/lingual gyrus), but not striate (cuneus), visual cortices contributed towards the reduced activity observed at sensor-level in ScZ patients. Importantly, differences in stimulus-related activity were not due to differences in baseline activity. CONCLUSIONS: Our findings highlight that MEG-measured high-frequency oscillations during visual processing can be robustly identified in ScZ. Our data further suggest impairments that involve dysfunctions in ventral stream processing and a failure to increase gamma-band activity in a task-context. Implications of these findings are discussed in the context of current theories of cortical-subcortical circuit dysfunctions and perceptual processing in ScZ.

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 Dates: 2016-06-252016-10
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.schres.2016.06.003
 Degree: -

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Title: Schizophrenia Research
  Alternative Title : Schizophrenia research
Source Genre: Journal
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Pages: - Volume / Issue: 176 (2-3) Sequence Number: - Start / End Page: 177 - 185 Identifier: ISBN: 1573-2509 (Electronic)0920-9964 (Linking)