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  Physiological basis of vascular autocalibration (VasA): Comparison to hypercapnia calibration methods

Kazan, S. M., Huber, L., Flandin, G., Ivanov, D., Bandettini, P., & Weiskopf, N. (2017). Physiological basis of vascular autocalibration (VasA): Comparison to hypercapnia calibration methods. Magnetic Resonance in Medicine, 78(3), 1168-1173. doi:10.1002/mrm.26494.

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Kazan_Huber_2016.pdf (Verlagsversion), 2MB
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 Urheber:
Kazan, Samira M.1, Autor
Huber, Laurentius2, Autor
Flandin, Guillaume1, Autor
Ivanov, Dimo3, Autor
Bandettini, Peter2, Autor
Weiskopf, Nikolaus1, 4, Autor           
Affiliations:
1Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
2Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA, ou_persistent22              
3Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Schlagwörter: Vascular reactivity; Vascularization differences; VasA; BOLD fMRI; BOLD calibration; SPM toolbox; VasA tool-box; Autorescaling
 Zusammenfassung: Purpose:
The statistical power of functional MRI (fMRI) group
studies is significantly hampered by high intersubject spatial
and magnitude variance. We recently presented a vascular
autocalibration method (VasA) to account for vascularization
differences between subjects and hence improve the sensitivi-
ty in group studies. Here, we validate the novel calibration
method by means of direct comparisons of VasA with more
established measures of baseline venous blood volume (and
indirectly vascular reactivity), the M-value.
Methods:
Seven healthy volunteers participated in two 7T (T)
fMRI experiments to compare M-values with VasA estimates:
(i) a hypercapnia experiment to estimate voxelwise M-value
maps, and (ii) an fMRI experiment using visual stimulation to
estimate voxelwise VasA maps.
Results:
We show that VasA and M-value calibration maps
show the same spatial profile, providing strong evidence that
VasA is driven by local variations in vascular reactivity as
reflected in the M-value.
Conclusion:
The agreement of vascular reactivity maps
obtained with VasA when compared with M-value maps con-
firms empirically the hypothesis that the VasA method is an
adequate tool to account for variations in fMRI response
amplitudes caused by vascular reactivity differences in healthy
volunteers. VasA can therefore directly account for them and
increase the statistical power of group studies. The VasA tool-
box is available as a statistical parametric mapping (SPM)
toolbox, facilitating its general application.

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Sprache(n): eng - English
 Datum: 2016-08-262016-05-092016-09-142016-11-092017-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/mrm.26494
PMID: 27851867
PMC: PMC5573956
Anderer: Epub ahead of print
 Art des Abschluß: -

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Projektinformation

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Projektname : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Talking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust

Quelle 1

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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 78 (3) Artikelnummer: - Start- / Endseite: 1168 - 1173 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149