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  Prevalence of DSM-5 mild neurocognitive disorder in dementia-free older adults: Results of the population-based LIFE-adult-study

Luck, T., Then, F. S., Schroeter, M. L., Witte, V., Engel, C., Loeffler, M., et al. (2017). Prevalence of DSM-5 mild neurocognitive disorder in dementia-free older adults: Results of the population-based LIFE-adult-study. The American Journal of Geriatric Psychiatry, 25(4), 328-339. doi:10.1016/j.jagp.2016.07.001.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-8506-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-C554-0
Genre: Journal Article

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 Creators:
Luck, Tobias1, 2, Author
Then, Francisca S.1, 2, Author
Schroeter, Matthias L.3, 4, Author           
Witte, Veronica3, 5, Author           
Engel, Christoph6, Author
Loeffler, Markus6, Author
Thiery, Joachim7, Author
Villringer, Arno3, 4, Author           
Riedel-Heller, Steffi G.1, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
7Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Mild neurocognitive disorder; Prevalence; Mild cognitive impairment; Dementia; Diagnostic and statistical manual of mental disorders (DSM-5)
 Abstract: Objective

The DSM-5 introduces mild neurocognitive disorder (miNCD) as a syndrome that recognizes the potential clinical importance of acquired cognitive deficits being too mild to qualify for diagnosis of dementia. We provide new empirical data on miNCD including total, age-, and sex-specific prevalence rates; number and types of neurocognitive domains being impaired; and diagnostic overlap with the well-established mild cognitive impairment (MCI) concept.
Design

Cross-sectional results of an observational cohort study (LIFE-Adult-Study).
Setting

General population.
Participants

A total of 1,080 dementia-free individuals, aged 60–79 years.
Measurements

We calculated weighted point prevalence rates with confidence intervals (95% CI) for miNCD and analyzed diagnostic overlap between miNCD and MCI by calculating overall percentage agreement and Cohen's kappa coefficient.
Results

Weighted total prevalence of miNCD was 20.3% (95% CI: 17.8–23.0). Prevalence was similar in both sexes, but significantly higher in older age. Two-thirds (66.2%) of the individuals with miNCD showed impairment restricted to only one out of six possible neurocognitive domains. Learning and memory was the most frequently (38.3%) impaired domain in all miNCD-cases, followed by social cognition (26.1%). Analysis of diagnostic overlap with MCI yielded an overall agreement of 98.6% and a kappa of 0.959.
Conclusions

By considering all six predefined neurocognitive domains, our study observed a substantial proportion of dementia-free older adults having miNCD. Provision of information on the underlying etiology/ies may be of prime importance in future studies aiming at evaluating the clinical relevance of the miNCD syndrome.

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Language(s): eng - English
 Dates: 2016-06-152016-01-222016-07-052016-07-072017-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.jagp.2016.07.001
PMID: 27618647
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Union (EU)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : European Social Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation

Source 1

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Title: The American Journal of Geriatric Psychiatry
  Abbreviation : Am J Geriatr Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 25 (4) Sequence Number: - Start / End Page: 328 - 339 Identifier: ISSN: 1064-7481
CoNE: https://pure.mpg.de/cone/journals/resource/1064-7481