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  Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection

Lenz, T. L., Spirin, V., Jordan, D. M., & Sunyaev, S. R. (2016). Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection. Molecular Biology and Evolution, 33(10), 2765-2766. doi:10.1093/molbev/msw146.

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http://mbe.oxfordjournals.org/content/33/10/2555 (Verlagsversion)
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 Urheber:
Lenz, Tobias L.1, Autor           
Spirin, Victor, Autor
Jordan, Daniel M., Autor
Sunyaev, Shamil R., Autor
Affiliations:
1Emmy Noether Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068286              

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Schlagwörter: balancing selection; exome; simulations; deleterious variation; mutation load; MHC/HLA
 Zusammenfassung: Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancing selection may counteract purifying selection in neighboring regions and thus maintain deleterious variants at higher frequency than expected from their detrimental fitness effect. We first show in realistic simulations that balancing selection reduces the density of polymorphic sites surrounding a locus under balancing selection, but at the same time markedly increases the population frequency of the remaining variants, including even substantially deleterious alleles. To test the predictions of our simulations empirically, we then use whole-exome sequencing data from 6,500 human individuals and focus on the most established example for balancing selection in the human genome, the major histocompatibility complex (MHC). Our analysis shows an elevated frequency of putatively deleterious coding variants in nonhuman leukocyte antigen (non-HLA) genes localized in the MHC region. The mean frequency of these variants declined with physical distance from the classical HLA genes, indicating dependency on genetic linkage. These results reveal an indirect cost of the genetic diversity maintained by balancing selection, which has hitherto been perceived as mostly advantageous, and have implications both for the evolution of recombination and also for the epidemiology of various MHC-associated diseases.

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Sprache(n): eng - English
 Datum: 2016-08-302016-10
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1093/molbev/msw146
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Titel: Molecular Biology and Evolution
  Andere : Mol. Biol. Evol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford : Oxford University Press
Seiten: - Band / Heft: 33 (10) Artikelnummer: - Start- / Endseite: 2765 - 2766 Identifikator: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119