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  Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P., Renteria, M. E., et al. (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience, 19, 1569-1582. doi:10.1038/nn.4398.

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Adams, Hieab H. H.1, Autor
Hibar, Derrek P.2, Autor
Chouraki, Vincent3, 4, Autor
Stein, Jason L.2, 5, Autor
Nyquist, Paul6, Autor
Renteria, Miguel E.7, Autor
Trompet, Stella8, Autor
Arias-Vasquez, Alejandro9, Autor
Seshadri, Sudha3, Autor
Desrivières, Sylvane10, Autor
Beecham, Ashley H.11, Autor
Jahanshad, Neda2, Autor
Wittfeld, Katharina12, Autor
Van der Lee, Sven J.1, Autor
Abramovic, Lucija13, Autor
Alhusaini, Saud14, Autor
Amin, Najaf1, Autor
Andersson, Micael15, Autor
Arfanakis, Konstantinos A.16, 17, Autor
Aribisala, Benjamin S.18, 19, Autor
Armstrong, Nicola J.20, 21, AutorAthanasiu, Lavinia22, AutorAxelsson, Tomas23, AutorBeiser, Alexa3, AutorBernard, Manon24, AutorBis, Joshua C.25, AutorBlanken, Laura M. E.1, AutorBlanton, Susan H.11, AutorBohlken, Marc M.13, AutorBoks, Marco P.13, AutorBralten, Janita9, AutorBrickman, Adam M.26, AutorCarmichael, Owen5, AutorChakravarty, M. Mallar14, 27, AutorChauhan, Ganesh28, AutorChen, Qiang29, AutorChing, Christopher R. K.2, 5, AutorCuellar-Partida, Gabriel6, AutorDen Braber, Anouk 30, AutorDoan, Nhat Trung22, AutorEhrlich, Stefan31, 32, AutorFilippi, Irina28, AutorGe, Tian32, 33, AutorGiddaluru, Sudheer34, AutorGoldman, Aaron L.29, AutorGottesman, Rebecca F.6, AutorGreven, Corina U.9, 10, AutorGrimm, Oliver35, AutorGriswold, Michael E.36, AutorGuadalupe, Tulio37, 38, Autor           Hass, Johanna31, AutorHaukvik, Unn K.20, 39, AutorHilal, Saima40, AutorHofer, Edith41, AutorHöhn, David42, AutorHolmes, Avram J.32, 43, AutorHoogman, Martine9, AutorJanowitz, Deborah12, AutorJia, Tianye10, AutorKarbalai, Nazanin42, AutorKasperaviciute, Dalia44, 45, AutorKim, Sungeun46, AutorKlein, Marieke9, AutorKrämer, Bernd47, AutorLee–, Phil H.32, AutorLiao, Jiemin48, AutorLiewald, David C. M.18, AutorLopez, Lorna M.18, AutorLuciano, Michelle18, AutorMacare, Christine10, AutorMarquand, Andre9, AutorMatarin, Mar44, AutorMather, Karen A.20, AutorMattheisen, Manuel49, AutorMazoyer, Bernard28, AutorMcKay, David R.43, AutorMcWhirter, Rebekah50, AutorMilaneschi, Yuri30, AutorMuetzel, Ryan L.1, AutorMuñoz Maniega, Susanna 17, 18, 19, AutorNho, Kwangsik46, AutorNugent, Allison C.51, AutorOlde Loohuis, Loes M.5, AutorOosterlaan, Jaap30, AutorPapmeyer, Martina18, 52, AutorPappa, Irene1, AutorPirpamer, Lukas41, AutorPudas, Sara15, AutorPütz, Benno42, AutorRajan, Kumar B.17, AutorRamasamy, Adaikalavan10, 44, 53, AutorRichards, Jennifer S.9, AutorRisacher, Shannon L.46, AutorRoiz-Santiañez, Roberto54, AutorRommelse, Nanda9, AutorRose, Emma J.55, AutorRoyle, Natalie A.18, AutorRundek, Tatjana11, AutorSämann, Philipp G.41, AutorSatizabal, Claudia L.3, AutorSchmaal, Lianne30, AutorSchork, Andrew J.5, AutorShen, Li46, AutorShin, Jean24, AutorShumskaya, Elena9, AutorSmith, Albert V.56, AutorSprooten, Emma18, 43, AutorStrike, Lachlan T.57, AutorTeumer, Alexander12, AutorThomson, Russell50, AutorTordesillas-Gutierrez, Diana54, AutorToro, Roberto58, AutorTrabzuni, Daniah44, 59, AutorVaidya, Dhananjay6, AutorVan der Grond, Jeroen 8, AutorVan der Meer, Dennis 60, AutorVan Donkelaar, Marjolein M. J.9, Autor           Van Eijk, Kristel R.13, AutorVanErp, Theo G. M.5, AutorVan Rooij, Daan 9, 60, AutorWalton, Esther31, AutorWestlye, Lars T.22, AutorWhelan, Christopher D.2, AutorWindham, Beverly G.36, AutorWinkler, Anderson M.43, AutorWoldehawariat, Girma51, AutorWolf, Christiane42, AutorWolfers, Thomas9, AutorXu, Bing10, AutorYanek, Lisa R.6, AutorYang, Jingyun17, AutorZijdenbos, Alex61, AutorZwiers, Marcel P.9, 62, AutorAgartz, Ingrid22, 39, 63, AutorAggarwal, Neelum T.17, AutorAlmasy, Laura64, AutorAmes, David65, AutorAmouyel, Philippe4, AutorAndreassen, Ole A.22, AutorArepalli, Sampath51, AutorAssareh, Amelia A.20, AutorBarral, Sandra5, AutorBastin, Mark E.18, AutorBecker, James T.66, AutorBecker, Diane M.59, AutorBennett, David A.17, AutorBlangero, John63, AutorVan Bokhoven, Hans9, AutorBoomsma, Dorret I.30, AutorBrodaty, Henry20, AutorBrouwer, Rachel M.13, AutorBrunner, Han G.9, 67, AutorBuckner, Randy L.32, 33, AutorBuitelaar, Jan K.9, AutorBulayeva, Kazima B.68, AutorCahn, Wiepke13, AutorCalhoun, Vince D.69, AutorCannon, Dara M.51, 70, AutorCavalleri, Gianpiero L.55, AutorChen, Christopher40, AutorCheng, Ching-Yu48, AutorCichon, Sven71, 72, 73, AutorCookson, Mark R51, AutorCorvin, Aiden55, AutorCrespo-Facorro, Benedicto54, AutorCurran, Joanne E.64, AutorCzisch, Michael42, AutorDale, Anders M.5, AutorDavies, Gareth E.74, AutorDe Geus, Eco J. 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Wouter8, AutorKahn, René S.13, AutorKanai, Ryota44, 90, 91, AutorKloszewska, Iwona92, AutorKnopman, David S.88, AutorKochunov, Peter89, AutorKwok, John B.20, 93, AutorLauner, Lenore J51, AutorLawrie, Stephen M.18, AutorLemaître, Hervé28, AutorLiu, Xinmin51, 94, AutorLongo, Dan L.78, AutorLongstreth Jr, W. T.25, AutorLopez, Oscar L.66, AutorLovestone, Simon10, 53, AutorMartinez, Oliver5, AutorMartinot, Jean-Luc95, AutorMattay, Venkata S.29, AutorMcDonald, Colm70, AutorMcIntosh, Andrew M.18, AutorMcMahon, Francis J.51, AutorMcMahon, Katie L.57, AutorMecocci, Patrizia96, AutorMelle, Ingrid22, AutorMeyer-Lindenberg, Andreas35, AutorMohnke, Sebastian77, AutorMontgomery, Grant W.7, AutorMorris, Derek W.55, 70, AutorMosley, Thomas H.36, AutorMühleisen, Thomas W.72, 73, AutorMüller-Myhsok, Bertram42, 97, 98, AutorNalls, Michael A.51, AutorNauck, Matthias12, AutorNichols, Thomas E.53, 99, AutorNiessen, Wiro J.1, 100, AutorNöthen, Markus M72, AutorNyberg, Lars15, AutorOhi, Kazutaka84, AutorOlvera, Rene L.64, AutorOphoff, Roel A.5, 13, AutorPandolfo, Massimo76, AutorPaus, Tomas24, 101, AutorPausova, Zdenka24, AutorPenninx, Brenda W. J. H.30, AutorPike, G. Bruce102, AutorPotkin, Steven G.5, AutorPsaty, Bruce M.25, 103, AutorReppermund, Simone20, AutorRietschel, Marcella35, AutorRoffman, Joshua L.32, AutorRomanczuk-Seiferth, Nina77, AutorRotter, Jerome I.5, AutorRyten, Mina10, 44, AutorSacco, Ralph L.11, AutorSachdev, Perminder S.20, 104, AutorSaykin, Andrew J.46, AutorSchmidt, Reinhold41, AutorSchofield, Peter R.20, 93, AutorSigursson, Sigurdur105, AutorSimmons, Andy10, AutorSingleton, Andrew51, AutorSisodiya, Sanjay M.44, AutorSmith, Colin18, AutorSmoller, Jordan W.32, 44, AutorSoininen, Hilkka106, AutorSrikanth, Velandai50, 107, AutorSteen, Vidar M.34, AutorStott, David J.79, AutorSussmann, Jessika E.18, AutorThalamuthu, Anbupalam20, AutorTiemeier, Henning1, 27, AutorToga, Arthur W.2, AutorTraynor, Bryan52, AutorTroncoso, Juan6, AutorTurner, Jessica A.108, AutorTzourio, Christophe29, AutorUitterlinden, Andre G.1, AutorValdés Hernández, Maria C. 18, AutorVan der Brug, Marcel 109, AutorVan der Lugt, Aad 1, AutorVan der Wee, Nic J. A. 8, AutorVan Duijn, Cornelia M.1, AutorVan Haren, Neeltje E. M.13, AutorVan 't Ent, Dennis 31, AutorVan Tol, Marie-Jose 60, AutorVardarajan, Badri N.27, AutorVeltman, Dick J.31, AutorVernooij, Meike W.1, AutorVölzke, Henry12, AutorWalter, Henrik78, AutorWardlaw, Joanna M.18, AutorWassink, Thomas H.85, AutorWeale, Michael E.10, AutorWeinberger, Daniel R.6, 30, AutorWeiner, Michael W.5, AutorWen, Wei20, AutorWestman, Eric63, AutorWhite, Tonya1, 94, AutorWong, Tien Y.40, 48, AutorWright, Clinton B.11, AutorZielke, Ronald H.89, AutorZonderman, Alan B.51, Autorthe Alzheimer's Disease Neuroimaging Initiative, EPIGEN, IMAGEN, SYS, Autor              Deary, Ian J.18, AutorDeCarli, Charles5, AutorSchmidt, Helena41, AutorMartin, Nicholas G.7, AutorDe Craen, Anton J. M.8, AutorWright, Margaret J.7, 57, AutorGudnason, Vilmundur56, 105, AutorSchumann, Gunter10, AutorFornage, Myriam64, AutorFranke, Barbara9, AutorDebette, Stéphanie3, 28, AutorMedland, Sarah E.7, AutorIkram, M Arfan1, AutorThompson, Paul M.2, Autor mehr..
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1Erasmus MC, Rotterdam, The Netherlands, ou_persistent22              
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10King's College London, London, UK, ou_persistent22              
11University of Miami, Miami, Florida, USA, ou_persistent22              
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31TU Dresden, Dresden, Germany, ou_persistent22              
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39Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
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 Zusammenfassung: Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late
life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438
adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were
also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height.
We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic
background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial
volume were also related to childhood and adult cognitive function, and Parkinson’s disease, and were enriched near genes
involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial
volume and provide genetic support for theories on brain reserve and brain overgrowth.

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Sprache(n): eng - English
 Datum: 20162016-10-032016
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/nn.4398
 Art des Abschluß: -

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Titel: Nature Neuroscience
  Andere : Nat. Neurosci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Nature America Inc.
Seiten: - Band / Heft: 19 Artikelnummer: - Start- / Endseite: 1569 - 1582 Identifikator: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931