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  Signaling mechanisms regulating B-lymphocyte activation and tolerance

Hobeika, E., Nielsen, P. J., & Medgysi, D. (2015). Signaling mechanisms regulating B-lymphocyte activation and tolerance. Journal of Molecular Medicine, 93, 143-158.

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 Urheber:
Hobeika, Elias1, 2, Autor           
Nielsen, Peter J.1, 2, Autor           
Medgysi, David1, 3, Autor
Affiliations:
1BIOSS Centre of Biological Signalling Studies, University of Freiburg and Department of Molecular Immunology, Faculty of Biology, University of Freiburg, Freiburg, Germany, ou_persistent22              
2Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              
3Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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Schlagwörter: B lymphocyte, B-cell tolerance, Autoimmunity, Inhibitory signaling
 Zusammenfassung: It is becoming more and more accepted that, in addition to producing autoantibodies, B lymphocytes have other important functions that influence the development of autoimmunity. For example, autoreactive B cells are able to produce inflammatory cytokines and activate pathogenic T cells. B lymphocytes can react to extracellular signals with a range of responses from anergy to autoreactivity. The final outcome is determined by the relative contribution of signaling events mediated by activating and inhibitory pathways. Besides the B cell antigen receptor (BCR), several costimulatory receptors expressed on B cells can also induce B cell proliferation and survival, or regulate antibody production. These include CD19, CD40, the B cell activating factor receptor, and Toll-like receptors. Hyperactivity of these receptors clearly contributes to breaking B-cell tolerance in several autoimmune diseases. Inhibitors of these activating signals (including protein tyrosine phosphatases, deubiquitinating enzymes and several adaptor proteins) are crucial to control B-cell activation and maintain B-cell tolerance. In this review, we summarize the inhibitory signaling mechanisms that counteract B-cell activation triggered by the BCR and the coreceptors.

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Sprache(n): eng - English
 Datum: 2015-02
 Publikationsstatus: Erschienen
 Seiten: 16
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: -
 Art des Abschluß: -

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Titel: Journal of Molecular Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: 16 Band / Heft: 93 Artikelnummer: - Start- / Endseite: 143 - 158 Identifikator: DOI: doi: 10.1007/s00109-015-1252-8