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  Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction

Bremser, A., Brack, M., & Izcue, A. (2015). Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction. Plos One, 10, e0137393. doi:doi: 10.1371/journal.pone.0137393.

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 Urheber:
Bremser, Anna1, 2, 3, Autor
Brack, Maria1, 2, Autor
Izcue, A.4, Autor           
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2Centre for Chronic Immunodeficiency (CCI), University Medical Center, Freiburg, Germany, ou_persistent22              
3Faculty of Biology, University of Freiburg, Freiburg, Germany, ou_persistent22              
4Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Zusammenfassung: T lymphocytes elicit specific responses after recognizing cognate antigen. However, antigen-experienced T cells can also respond to non-cognate stimuli, such as cytokines. CD4+ Foxp3+ regulatory T cells (Treg) exhibit an antigen-experienced-like phenotype. Treg can regulate T cell responses in an antigen-specific or bystander way, and it is still unclear as to which extent they rely on T cell receptor (TCR) signals. The study of the antigen response of Treg has been hampered by the lack of downstream readouts for TCR stimuli. Here we assess the effects of TCR signals on the expression of a classical marker of early T cell activation, CD69. Although it can be induced following cytokine exposure, CD69 is commonly used as a readout for antigen response on T cells. We established that upon in vitro TCR stimulation CD69 induction on Foxp3+ Treg cells was more dependent on signaling via soluble factors than on TCR activation. By contrast, expression of the activation marker Nur77 was only induced after TCR stimulation. Our data suggest that Treg are more sensitive to TCR-independent signals than Foxp3- cells, which could contribute to their bystander activity.

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Sprache(n): eng - English
 Datum: 2015-09-09
 Publikationsstatus: Erschienen
 Seiten: 15
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: doi: 10.1371/journal.pone.0137393
 Art des Abschluß: -

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Titel: Plos One
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Sciene
Seiten: - Band / Heft: 10 Artikelnummer: - Start- / Endseite: e0137393 Identifikator: ISSN: 1932-6203
Anderer: 1000000000277850
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850