English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding

Hayer-Hartl, M., Bracher, A., & Hartl, F. U. (2016). The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding. Trends in Biochemical Sciences: TIBS / International Union of Biochemistry and Molecular Biology., 41(1; Special Issue: 40 Years of TiBS), 62-76. doi:10.1016/j.tibs.2015.07.009.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Hayer-Hartl, Manajit1, 2, Author           
Bracher, Andreas2, Author           
Hartl, F. Ulrich2, Author           
Affiliations:
1Hayer-Hartl, Manajit / Chaperonin-assisted Protein Folding, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565153              
2Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

Content

show
hide
Free keywords: ESCHERICHIA-COLI; IN-VIVO; SUBSTRATE PROTEIN; MASS-SPECTROMETRY; REACTION CYCLE; E. COLI; CONFORMATIONAL-CHANGES; MOLECULAR CHAPERONES; FUNCTIONAL FORM; COMPLEX
 Abstract: The bacterial chaperonin GroEL and its cofactor GroES constitute the paradigmatic molecular machine of protein folding. GroEL is a large double-ring cylinder with ATPase activity that binds non-native substrate protein (SP) via hydrophobic residues exposed towards the ring center. Binding of the lid-shaped GroES to GroEL displaces the bound protein into an enlarged chamber, allowing folding to occur unimpaired by aggregation. GroES and SP undergo cycles of binding and release, regulated allosterically by the GroEL ATPase. Recent structural and functional studies are providing insights into how the physical environment of the chaperonin cage actively promotes protein folding, in addition to preventing aggregation. Here, we review different models of chaperonin action and discuss issues of current debate.

Details

show
hide
Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Trends in Biochemical Sciences : TIBS / International Union of Biochemistry and Molecular Biology.
  Other : TRENDS BIOCHEM SCI
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 41 (1; Special Issue: 40 Years of TiBS) Sequence Number: - Start / End Page: 62 - 76 Identifier: ISSN: 0376-5067
CoNE: https://pure.mpg.de/cone/journals/resource/954925582191