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  Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

Freschi, L., Jeukens, J., Kukavica-Ibrulj, I., Boyle, B., Dupont, M. J., Laroche, J., et al. (2015). Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology, 6: 1036. doi:10.3389/fmicb.2015.01036.

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Freschi, Luca, Autor
Jeukens, Julie, Autor
Kukavica-Ibrulj, Irena, Autor
Boyle, Brian, Autor
Dupont, Marie Josee, Autor
Laroche, Jérôme, Autor
Larose, Stéphane, Autor
Maaroufi, Halim, Autor
Fothergill, Joanne L., Autor
Moore, Matthew, Autor
Winsor, Geoffrey L., Autor
Aaron, Shawn D., Autor
Barbeau, Jean, Autor
Bell, Scott C., Autor
Burns, Jane L., Autor
Camara, Miguel, Autor
Cantin, André, Autor
Charette, Steve J., Autor
Dewar, Ken, Autor
Déziel, Éric, Autor
Grimwood, Keith, AutorHancock, Robert E. W., AutorHarrison, Joe J., AutorHeeb, Stephan, AutorJelsbak, Lars, AutorJia, Baofeng, AutorKenna, Dervla T., AutorKidd, Timothy J., AutorKlockgether, Jens, AutorLam, Joseph S., AutorLamont, Iain L., AutorLewenza, Shawn, AutorLoman, Nick, AutorMalouin, Francois, AutorManos, Jim, AutorMcArthur, Andrew G., AutorMcKeown, Josie, AutorMilot, Julie, AutorNaghra, Hardeep, AutorNguyen, Dao, AutorPereira, Sheldon K., AutorPerron, Gabriel G., AutorPirnay, Jean-Paul, AutorRainey, Paul B.1, Autor           Rousseau, Simon, AutorSantos, Pedro M., AutorStephenson, Anne, AutorTaylor, Véronique, AutorTurton, Jane F., AutorWaglechner, Nicholas, AutorWilliams, Paul, AutorThrane, Sandra W., AutorWright, Gerard D., AutorBrinkman, Fiona S. L., AutorTucker, Nicholas P., AutorTümmler, Burkhard, AutorWinstanley, Craig, AutorLevesque, Roger C., Autor mehr..
Affiliations:
1External Scientific Member Group Experimental and Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445637              

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Schlagwörter: antibiotic resistance; antibiotic sensitivity; Article; bacterial genetics; bacterial genome; bacterial virulence; bioinformatics; cystic fibrosis; human; lung infection; microbial consortium; next generation sequencing; nonhuman; phylogeny; population structure; Pseudomonas aeruginosa; single nucleotide polymorphism
 Zusammenfassung: The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aeruginosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P. aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care. © 2015 Freschi, Jeukens, Kukavica-Ibrulj, Boyle, Dupont, Laroche, Larose, Maaroufi, Fothergill, Moore, Winsor.

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Sprache(n): eng - English
 Datum: 2015-05-132015-09-112015-09-292015
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.3389/fmicb.2015.01036
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Titel: Frontiers in Microbiology
  Kurztitel : Front. Microbiol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Lausanne : Frontiers Media
Seiten: - Band / Heft: 6 Artikelnummer: 1036 Start- / Endseite: - Identifikator: ISSN: 1664-302X
CoNE: https://pure.mpg.de/cone/journals/resource/1664-302X