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  Synthetic histone code.

Fischle, W., Mootz, H., & Schwarzer, D. (2015). Synthetic histone code. Current Opinion in Chemical Biology, 28, 131-140. doi:10.1016/j.cbpa.2015.07.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-06D5-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-B913-D
Genre: Journal Article

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2227871.pdf (Publisher version), 2MB
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 Creators:
Fischle, W.1, Author              
Mootz, H., Author
Schwarzer, D., Author
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1Research Group of Chromatin Biochemistry, MPI for biophysical chemistry, Max Planck Society, escidoc:578604              

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 Abstract: Chromatin is the universal template of genetic information in all eukaryotic cells. This complex of DNA and histone proteins not only packages and organizes genomes but also regulates gene expression. A multitude of posttranslational histone modifications and their combinations are thought to constitute a code for directing distinct structural and functional states of chromatin. Methods of protein chemistry, including protein semisynthesis, amber suppression technology, and cysteine bioconjugation, have enabled the generation of so-called designer chromatin containing histones in defined and homogeneous modification states. Several of these approaches have matured from proof-of-concept studies into efficient tools and technologies for studying the biochemistry of chromatin regulation and for interrogating the histone code. We summarize pioneering experiments and recent developments in this exciting field of chemical biology.

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Language(s): eng - English
 Dates: 2015-08-062015-10
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cbpa.2015.07.005
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Title: Current Opinion in Chemical Biology
Source Genre: Journal
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Pages: - Volume / Issue: 28 Sequence Number: - Start / End Page: 131 - 140 Identifier: -